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The National Eye Institute is putting our best to the ultimate test. The National Eye Institute (NEI) is using DSM eye health nutrients in a major study. Scientific evidence suggests that nutrients such as lutein, zeaxanthin and omega-3 fatty acids can play a beneficial role in maintaining eye health. The National Eye Institute is conducting its second comprehensive Age-Related Eye Disease Study (AREDS2) to assess the effects of these nutrients on the progression of age-related macular
degeneration and is using DSM’s FloraGLO® Lutein, OPTISHARP® Zeaxanthin and Ropufa® Omega-3 fatty acids in this key clinical trial. A recognized global leader in eye health, with more than 100 years of experience in health and nutrition, DSM is proud to participate in this groundbreaking NEI study. To find out more about how DSM solutions and our protective Actilease® beadlet technology can enhance your eye health products, visit www.optisharpandfloraglo.com or call 1-800-526-0189.
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Table of Contents June 2011 • Volume 14, No. 5
36 Soy Story Soy has had a wild ride during the past decade, and it’s not over yet.
Cover design by: Sara Downing
44 (R)evolution in Flavors & Colors
44
Balancing flavor with healthfulness while keeping costs low may prove to be the magic formula.
50
50 A Bright Outlook for Oral Care As research develops, more companies will be sinking their teeth into fresh opportunities.
Columns 26 • Business Insights by Greg Stephens & Sheila Campbell
30 • Eurotrends by Joerg Gruenwald 32 • Quality Focus by Paula Brown
28 • Capitol Comments by Todd Harrison & Seung-Hyun Ryu 4 • Nutraceuticals World
34 • Research Process by Doug Kalman
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June 2011
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Table of Contents
15
58
59
Departments 8 • Top Of The News • Pharmacists recommend and take dietary supplements 10 • Editorial • a word from the editor 12 • Nutraceuticals World In Print & Online • line-up of expanded coverage @ nutraceuticalsworld.com 14 • Industry News • Helsinn & Thorne to provide supplements to cancer patients 56 • Nutraceuticals Research • a recap of the latest clinical trials 58 • Supply Source • profile on Consumer Product Testing Co. 59 • New Products • recent nutraceutical product introductions 61 • Suppliers Corner • new developments from industry suppliers 64 • People In The News • who’s who and who’s moving where 64 • Classified Section • classified advertising section 65 • Calendar • upcoming industry events 65 • Advertisers Index • cross reference of advertisers in this issue 66 • The Nutraceuticals Multiverse • a quirky look at nutraceuticals in a parallel universe NUTRACEUTICALS WORLD’S circulation is audited by BPA International. Authorization to photocopy items in NUTRACEUTICALS WORLD for internal or personal use, or internal or personal use of specific clients, is granted by Rodman Publishing, provided a base fee of U.S. $1 per page is paid directly to: Copyright Clearance Center, 27 Salem St., Salem, MA 01970 USA. NUTRACEUTICALS WORLD (ISSN 1531 0671) is published 10 times a year (Jan/Feb; March; April; May; June; July/August; September; October; November, December), in addition to a Company Capabilities supplement and Beauty I&O supplement, by Rodman Publishing Corporation, 70 Hilltop Road, Ramsey, NJ 07446 USA. Phone: 201-825-2552. Fax: 201-825-0553. Periodical postage paid at Ramsey, NJ 07446 and additional mailing offices. Publications Mail Agreement No: 40028970: Return Undeliverable Canadian Addresses to Circulation Dept. or PO Box 1051, Fort Erie, ON L2A 6C7;
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6 • Nutraceuticals World
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June 2011
Top Of The News
“Pharmacists are able to help consumers choose the types of supplements that are right for their individual wellness plan.” —Douglas MacKay, ND, CRN
Pharmacists Recommend and Take Dietary Supplements
Pharmacists have become an influential information source for consumers, answering questions about dietary supplements and offering recommendations to their customers. Additionally, pharmacists themselves are incorporating dietary supplements into their lives as a means of increasing their overall health and wellness. According to research from the“Life…Supplemented”Healthcare Professionals (HCP) Impact Study, 93% of pharmacists recommend supplements to their customers, while 87% believe supplements can play an important role in improving or maintaining the health of their customers. “Pharmacists are able to help consumers choose the types of supplements that are right for their individual wellness plan,”said Douglas MacKay, ND, vice president, Scientific & Regulatory Affairs, Council for Responsible Nutrition (CRN), Washington, D.C., and a consultant to the “Life…supplemented” consumer wellness initiative. “A pharmacist’s training specifically qualifies him or her to take a comprehensive look at an individual’s current prescribed medications and determine if any potential drug-dietary supplement interactions or drug-induced nutrient depletions may need to be addressed. To maximize benefits and safety it is important to talk to a pharmacist or other qualified healthcare practitioner about all the things you are taking for your health.” Eighty four percent of pharmacists said they believe it is a good idea for customers to take supplements, citing joint health (65%), bone health (61%) and flu/colds (51%) as the top three reasons they have recommended supplements to their customers. Pharmacists also noted in the survey that when they did speak to customers about supplements, two thirds reported customers had initiated the conversation. With regard to which supplements pharmacists were most often asked about, the top three mentioned by respondents were omega 3/fish oil (mentioned by 73%), calcium (73%) and glucosamine/chondroitin (70%). Pharmacists, like many other healthcare populations, also were willing to take their own counsel when it comes to supplements. Nearly nine in 10 pharmacists said they use dietary supplements (86%), citing “overall health and wellness”(44%) and“filling in nutrient gaps”(40%) as the top two reasons they personally take them. Seventy six percent of those surveyed indicated they take a multivitamin; other popular supplements taken by pharmacists include omega 3/fish oil (35%), calcium (35%), vitamin C (32%), B vitamins (25%), vitamin D (23%) and fiber (19%).
Researchers Share Puzzling Findings on Omega 3s and Prostate Cancer Risk
The largest study ever to examine the association of dietary fats and prostate cancer risk has found what’s good for the heart may not be good for the prostate. Analyzing data from a nationwide study involving more than 3400 men, researchers at Fred Hutchinson Cancer Research Center found that men with the highest blood percentages of DHA had two-and-a-half-times the risk of developing aggressive, high-grade prostate cancer compared to men with the lowest DHA levels. Conversely, the study also found that men with the highest blood ratios of trans-fatty acids—which are linked to inflammation and heart disease and abundant in processed foods that contain partially hydrogenated vegetable oils—had a 50% reduction in the risk of high-grade prostate cancer. In addition, neither of these fats was associated with the risk of low-grade prostate cancer risk. The researchers also found that omega 6 fatty acids,
8 • Nutraceuticals World
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June 2011
Top Of The News
which are found in most vegetable oils and are linked to inflammation and heart disease, were not associated with prostate cancer risk. These findings by Theodore Brasky, PhD, and colleagues in the Hutchinson Center’s Public Health Sciences Division were published online April 25 in the American Journal of Epidemiology. “We were stunned to see these results and we spent a lot of time making sure the analyses were correct,”said Dr. Brasky, a postdoctoral research fellow in the Hutchinson Center’s Cancer Prevention Program. “Our findings turn what we know—or rather what we think we know—about diet, inflammation and the development of prostate cancer on its head and shine a light on the complexity of studying the association between nutrition and the risk of various chronic diseases.” The researchers undertook the study because chronic inflammation is known to increase the risk of several cancers, and the omega 3 fatty acids found primarily in fish and fish oil supplements have anti-inflammatory effects. In contrast, other fats, such as the omega 6 fats in vegetable oil and trans-fats found in fast foods, may promote inflammation. “We wanted to test the hypothesis that the concentrations of these fats in blood would be associated with prostate cancer risk,”Dr. Brasky said.“Specifically, we thought that omega 3 fatty acids would reduce and omega 6 and trans-fatty acids would increase prostate cancer risk.” The mechanisms behind the impact of omega 3s on risk of high-grade prostate cancer are unknown.“Besides inflammation, omega 3 fats affect other biologic processes. It may be that these mechanisms play a greater role in the development of certain prostate cancers,”Dr. Brasky said.“This is certainly an area that needs more research.” Currently, there is no official Recommended Daily Allowance (RDA) for omega 3 fats for adults or children, although many nutrition experts and physicians recommend 450 mg of omega 3 DHA per day as part of a healthy diet. The study was based on data from the Prostate Cancer Prevention Trial, a nationwide randomized clinical trial that tested the efficacy of the drug finasteride to prevent prostate cancer. While the trial involved nearly 19,000 men age 55 and older, the data in this analysis came from a subset of more than 3000 of the study participants, half of whom developed prostate cancer during the course of the study and half of whom did not. The clinical trial was unique in that prostate biopsy was used to confirm the presence or absence of prostate cancer in all study participants. Among the study participants, very few took fish oil supplements—the most common non-food source of omega 3 fatty acids, which are known to prevent heart disease and other inflammatory conditions. The majority got omega 3s from eating fish. So based on these findings, should men concerned about heart disease eschew fish oil supplements or grilled salmon in the interest of reducing their risk of aggressive prostate cancer? Dr. Brasky and colleagues don’t think so. “Overall, the beneficial effects of eating fish to prevent heart disease outweigh any harm related to prostate cancer risk,” Dr. Brasky said.“What this study shows is the complexity of nutrition and its impact on disease risk, and that we should study such associations rigorously rather than make assumptions.” The National Cancer Institute (NCI) funded this study, which also involved researchers from the University of Texas Health Science Center at San Antonio and the NCI. June 2011
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Nutraceuticals World • 9
From The Editor
Nestlé Has Seen the Light—Have You? People have been buzzing about personalized nutrition for years, with little or nothing to show for it in terms of big market introductions or widespread consumer acceptance. Well, Nestlé hopes to change that. On May 24, Nestlé Health Science acquired Prometheus Labs, a California maker of medical devices and pharmaceuticals for the gastrointestinal market. This is the business unit’s third purchase in less than eight months, according to a Dow Jones article. Analysts speculate Nestlé paid between $500 million and $1 billion for the company. To recap, Nestlé Health Science was formed to create nutritional solutions for people with specific dietary needs related to illnesses, disease states or the special challenges of different life stages. To further these efforts, in late March it acquired CM&D Pharma, a small Switzerlandbased drug company specializing in kidney disease, IBD and colon cancer. The company’s leading product, Fostrap, is a “medical food” in the form of a chewing gum fortified with chitosan for kidney patients who have an elevated level of phosphate in the blood (i.e., hyperphosphataemia). While this condition is rare in the general population, it commonly affects patients with kidney failure or renal insufficiency. Prior to the CM&D deal, Nestlé Health Science purchased Vitaflo, a U.K.-based clinical nutrition company, which develops products for infants, children and adults with genetic disorders that affect how food is processed by the body—e.g., phenylketonuria (PKU), maple syrup urine disease (MSUD) and homocystinuria (HCU). From specially formulated omega 3 supplements to protein shots, the company produces a wide range of products that offer nutritional and metabolic support. About the latest buy, Luis Cantarell, Nestlé Health Science president and CEO, said, “This acquisition is a strategic move into gastrointestinal diagnostics. Prometheus’s leading edge diagnostics and highly experienced medical sales representatives together constitute a robust platform for Nestlé Health Science to accelerate its current and future healthcare business. It will enable new personalized healthcare solutions based on diagnostics, pharma and nutrition.” This means Nestlé Health Science will have the capability to offer both diagnosis and treatment with pharmaceuticals and nutrition products. Finally, we have a company with a strong interest in linking food, pharmaceuticals, medical devices and dietary supplements—a company that believes consumers deserve more than pharmaceuticals when it comes to their medical needs. Is this the wave of the future? And are other companies likely to follow suit? Datamonitor analyst Mark Whalley thinks so.“The current market’s personalized food and beverage offerings are likely only a small representation of what’s to come. As interest amongst consumers increases, we expect to see a surge in the number of food and drink companies launching products with DNA/genetic influences over the next few years, probably originating from smaller niche companies looking to find gaps in the market.” Mr. Whalley also said the concept of personalized nutrition is lucrative if approached effectively. “Most of the big food and beverage players will be identifying this as something interesting to consider for the long term.”Certainly Nestlé wouldn’t spend upward of $1 billion if it didn’t believe in the future of personalized nutrition. According to Greek mythology, the god Prometheus bestowed the gift of fire to mortals on earth, bringing them warmth and light to relieve their suffering in the darkness. Obviously Nestlé has seen the light. I hope the healthcare world will too.
Editor: Rebecca Wright (
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Columnists Anthony Almada MSc GENr8, Inc.
Paul Altaffer RFI Ingredients, Inc.
Paula Brown British Columbia Institute of Technology
Jeff Crowther The Natural Products Association (NPA), China
Erik Goldman Holistic Primary Care
Joerg Gruenwald analyze & realize AG
Todd Harrison Venable LLP
Adam Ismail Global Organization for EPA & DHA (GOED)
Doug Kalman Miami Research Associates
Dr. A. Elizabeth Sloan Sloan Trends, Inc.
Grant Washington-Smith Alticor, Inc.
Editorial Advisory Board Steve Allen Nutrition Capital Network
Nancy Childs, PhD Saint Joseph’s University
Steven Dentali, PhD American Herbal Products Association (AHPA)
Loren Israelsen United Natural Products Alliance (UNPA)
Alex Merolli Nutri+Food Business Consultants
Paul Paslaski BioVittoria Limited
Ellen Schutt LaunchNatural
Scott Steinford ZMC USA
Gregory Stephens, RD (Business Insights Columnist) Windrose Partners
Rhonda Witwer National Starch Food Innovation
10 • Nutraceuticals World
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June 2011
Stay connected with
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The New NutraceuticalsWorld.com Nutraceuticals World launched a redesigned website last year, featuring expanded content, enhanced navigational tools and additional resources that streamline access to our comprehensive archive of market information.
Knowledge Center In an effort to help you access more than 10,000 articles from the past 12 years of Nutraceuticals World’s coverage, we have created a “Knowledge Center,” which contains a growing base of information designed to offer you the most relevant news and articles associated with specific categories in the nutraceuticals industry. We have divided the Knowledge Center into two sub-categories—Nutraceuticals Markets and Health Conditions, which are divided further into nearly 50 unique sections, such as Antioxidants, Baby Boomers, Cardiovascular Health, Immune Function and Sports Nutrition.
TrendSense Industry expert Liz Sloan is flexing her marketing muscles, offering analysis on different segments each month using Sloan Trends’TrendSense models. You can find her analysis, complete with downloadable TrendSense Data Charts, under the “Research” tab of our website.
Top Online Stories @ nutraceuticalsworld.com What is Pterostilbene? The berry-derived ingredient is proving to be a potent antioxidant and cardiovascular system supporter.
The Rising of the Green Sun Defying the economic downturn, greenfoods are stronger than ever.
Minerals: The Next Generation The market continues to evolve in light of consumer demands, new applications and emerging technologies.
‘Naturally Filtered’ Blog Each month associate editor Sean Moloughney will offer his thoughts on emerging trends. Look for his blog under the “Opinions” tab of our website.
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Industry News
Helsinn & Thorne to Provide Supplements to Cancer Patients Looking to develop, acquire and market a range of dietary supplements and other products specifically formulated to meet the unique requirements of cancer patients, Helsinn Group, Lugano, Switzerland, has completed a minority investment in Thorne Research, Inc., which develops and manufactures nutritional supplements marketed through licensed healthcare practitioners. In addition to nutritional supplement products, Helsinn and Thorne will pursue the development of medical information and supportive services for healthcare professionals and their patients. The venture will initially be directed at cancer supportive care, cancer pain management and other areas of oncology, and may ultimately be broadened to other disease areas. The deal will create a dedicated natural products division in cancer supportive care within Thorne Research.
Dr. Sears Blames Obesity Crisis on Omega 3-6 Imbalance Disproportionately high levels of omega 6 fatty acids in U.S. diets and the need for more omega 3 oils are at the heart of the country’s obesity crisis, according to Dr. Barry Sears, best-selling author of The Zone, creator of the Zone Diet and founder of ZoneDiet.com. “Relying simply on eating less and exercising more is not enough because the obesity problem is far more intricate,” Dr. Sears said. “Too many omega 6 fatty acids in the diet promote inflammation, while omega 3 fatty acids decrease inflammation. People need a one-to-one balance of omega 6 to omega 3 in the diet, just like it was a century ago, rather than today’s approximate 20:1 ratio.” Omega 3 is found in fish oils, walnuts and spinach. Omega 6 is in low-cost vegetable oils, such as corn oil and soybean oil.“Cutting omega 6 is not easy since, as taxpayers, 14 • Nutraceuticals World
“Cutting omega 6 is not easy since, as taxpayers, we spend about $20 billion a year subsidizing agribusiness to produce food ingredients that make us more inflamed.” —Dr. Barry Sears, Zone Diet Creator we spend about $20 billion a year subsidizing agribusiness to produce food ingredients that make us more inflamed. These are some of the most common ingredients in the foods today, as virtually all processed food in supermarket aisles contains omega 6 fatty acids,” Dr. Sears said. The nation’s obesity crisis has resulted in significantly higher incidences of weight-related health issues, from diabetes to heart problems, he noted. “When parents stopped giving their children fish oil, such as a tablespoon of codliver oil a day, as they did a generation or two ago, America started to get fatter. It tastes terrible, but a tablespoon of cod-liver oil has about 2.5 grams of omega 3 fatty acids, and that is enough to turn back the inflammatory tide that is at the base of so many health issues,”he said.
Survey Identifies Communication Gap on Child Nutrition New findings from the NOURISH (KNOwledge, UndeRstanding & InsightS Into CHild Nutrition) survey reveal that nearly half (47%) of healthcare professionals (HCPs) surveyed globally believe most parents of children they see still do not fully understand the long-term impact of early nutrition. Despite regular dialogue with parents about an optimal balance of nutrients during their child’s first five years of life, HCPs reported that when it comes to feeding and nutrition, less than one-fifth (17%) of parents are “very concerned” about ensuring their child is getting the right balance of nutrients they need. The NOURISH survey also revealed an opportunity to provide parents with additional guidance and education about healthy growth and appropriate feeding practices for infants and young children. Globally, in 2010, around 43 million children under the age of five were overweight. Proper nutrition means getting an optimal balance of nutrients; however, too much of certain nutrients—even those www.nutraceuticalsworld.com
that are important for a child’s development—can negatively affect long-term health outcomes. Over-nutrition, or the over-consumption of certain foods or food components, may contribute to heart disease, stroke, diabetes and cancer.
Nestlé Waters to Acquire Sweet Leaf Nestlé Waters North America, Stamford, CT, has signed an agreement to acquire the Sweet Leaf Tea Company, Austin, TX, including its Sweet Leaf and Tradewinds beverage brands. The acquisition, which remains subject to regulatory approval and satisfaction of other customary closing conditions, will expand Nestlé Waters’portfolio of bottled water to include high quality iced teas, lemonades and juices. It follows an initial investment by Nestlé Waters in the Sweet Leaf brand in March 2009. The acquisition will bring Nestlé Waters’ increased capabilities to the company’s operations, allowing it to make Sweet Leaf and Tradewinds beverages available to more people across the U.S.
European Commission Authorizes Three DHA Claims, Rejects One In early May, the EU Commission approved three Article 14 DHA claims related to children’s development and rejected one claim related to ARA/DHA and brain development in infants and young children. As of May 26, the following three claims can be made on foods on the EU market: 1. Docosahexaenoic acid (DHA) intake contributes to the normal visual development of infants up to 12 months of age. (This is the claim that received so much attention in recent months, which the Global Organization for EPA and DHA Omega-3s, GOED, Salt Lake City, UT, reported on three separate times: March 16, April 1 and most recently, April 6.) Conditions of use: Information shall be given to the consumer that the benefiJune 2011
Industry News
cial effect is obtained with a daily intake of 100 mg of DHA. When the claim is used on follow-on formula, the food shall contain at least 0.3% of the total fatty acids as DHA. 2. Docosahexaenoic acid (DHA) maternal intake contributes to the normal de-
velopment of the eye of the fetus and breastfed infants. Conditions of use: Information shall be given to pregnant and lactating women that the beneficial effect is obtained with a daily intake of 200 mg of DHA in addition to the recommended
Price Rivals Taste as Top Influencer for American Buying Habits
daily intake for omega 3 fatty acids for adults, i.e. 250 mg DHA and eicosapentaenoic acid (EPA). The claim can be used only for food, which provides a daily intake of at least 200 mg DHA. 3. Docosahexaenoic acid (DHA) maternal intake contributes to the normal brain de-
Increasingly for Americans, the cost of food is becoming almost as important as the taste of it, according to the International Food Information Council (IFIC) Foundation “2011 Food & Health
director of Trends and Consumer Insights at the IFIC Foundation. “This would be consistent with current trends toward small indulgences and a shift in perception about food in which consumers are seeking to be empowered rather than educated about food, health and food safety practices.”
Survey.” Although taste remains the top consideration (87%), 79% of consumers say price impacts their decision when deciding which foods and beverages to purchase, a 6% increase from 2010 and a noteworthy 15% increase since 2006. While healthfulness (66%), convenience (58%) and sustainability (52%) play roles in consumer decision-making, no other motivator rose at the same rate as price during the past five years. Interestingly, these trends are consistent with what drives Americans’ menu decisions at restaurants: taste (69%) and price (61%) are ranked as the top two motivators. Americans also say lower prices are the top driver that would lead them to make more healthful choices when shopping for food. “The economy seems to be having a significant effect on what people look for when buying food,” said Marianne Smith Edge, MS, RD, senior vice president of Food Safety and Nutrition at the IFIC Foundation. “While Americans will almost always choose foods that taste good first, they’re certainly looking for affordable, healthful foods as well.” The IFIC Foundation “2011 Food and Health Survey” also found significantly fewer Americans are concerned about their weight status when compared to last year; 50% of Americans described themselves as overweight in 2011 compared to 57% in 2010. More Americans perceived their diet as extremely or somewhat healthful (62%) when compared to 2010 (53%). At the same time, fewer Americans report making dietary changes (59% in 2011 compared to 64% in 2010) and more Americans report their physical activity levels are sedentary (43%)—a significant increase from 2010 (37%). These contradictions are further evidenced by the fact that the number of people trying to lose or maintain weight (69%) has significantly decreased since 2010 (77%). “This contradiction may indicate that Americans are being less hard on themselves and less critical of their health and wellbeing than in past years, despite an environment in which improved health and wellness is increasingly discussed from the media to government to the dinner table,” said Carrie Dooher,
The IFIC Foundation “2011 Food & Health Survey” captured the thoughts, perceptions, and behaviors of 1000 American adults over a Americans are being less hard on themselves and less critical two and a half-week period in of their health and well-being March and April of 2011. than in past years. Additional findings from the International Food Information Council Foundation “2011 Food & Health Survey” include: • Americans’ awareness of the Dietary Guidelines for Americans has increased (81% in 2011 compared to 71% in 2010). Still, 95% of Americans could not name another “healthy living” initiative beyond the Dietary Guidelines for Americans or MyPyramid, such as First Lady Michelle Obama’s Let’s Move! campaign. • Despite significant attention on sodium, Americans’ concern about sodium remains stable. A little more than half of Americans (53%) say they are very or somewhat concerned about their sodium intake, equal to last year (53%). • Sixty-one percent of Americans believe that imported food is less safe than foods produced in the U.S., citing less regulation as the top reason. Trust in the safety of the U.S. food supply, however, remains stable. Half of Americans are extremely or somewhat confident in the safety of the U.S. food supply, similar to previous years. The top U.S. food safety concern continues to be foodborne illness (50% in 2011). • Only 9% of Americans can accurately estimate the number of calories they should consume in a day for a person of their age, height, weight and physical activity. The majority of Americans do not keep track of calories consumed or burned, citing numerous barriers, including extreme difficulty and a lack of interest, knowledge and focus. • Despite the popularity of some “food rules” that suggest certain foods to avoid, Americans say they would rather hear what to eat (63%) instead of what not to eat. The interest in positive messaging rose 7% since 2009 when the survey last polled Americans on this sentiment.
Survey reveals economic impact of consumer purchases and perceptions.
June 2011
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Nutraceuticals World • 15
Industry News
velopment of the fetus and breastfed infants. Conditions of use: Information shall be given to pregnant and lactating women that the beneficial effect is obtained with a daily intake of 200 mg of DHA in addition
to the recommended daily intake for omega 3 fatty acids for adults, i.e. 250 mg DHA and EPA. The claim can be used only for food, which provides a daily intake of at least 200 mg DHA.
The health claim rejected by the Commission, “Docosahexaenoic acid (DHA) and arachidonic acid (ARA) contribute to the optimal brain development of infants and young children,” may be used for
foods/drinks and videos, according to Marketdata Enterprises’ “The U.S. Weight Loss & Diet Control Market, May 2011.” Marketdata Enterprises reports sales of the top eight commercial weight loss chains reached $3.14 billion in 2010, online dieting sales $238 million and diet home delivery sales $924 million.
Getting Ahead of the Curve: Protein & Weight Loss By Dr. A. Elizabeth Sloan While low carb may have been one of the hottest diet fads of all time, it’s high protein that’s long been the winner in the war on weight. Among adults trying to lose weight, 55% made a strong effort to increase their protein intake, up from 50% in 2007, according to the “2010 Gallup Study of Weight Management.” Those making a strong effort to limit carbs declined among current dieters from 39% to 33%. Moreover, with consumers associating protein with other important weight loss needs—including feeling full, building muscle/body toning, increased energy and lowering cholesterol for those on condition-directed weight loss plans—the future potential for high protein products is awesome indeed. And, the timing is right. While the economy kept growth in the $61 billion U.S. weight loss industry—which includes foods, supplements, Bariatric surgery, videos, etc.—to less than 1%, it caused “dieters” to further shift to low cost do-it-yourself diet plans, e.g., diet websites, OTC diet pills, meal replacements, low calorie
Market Potential According to Sloan Trends’ TrendSense Model, protein and weight is a very large, strong and stable Level 2 mass-market opportunity on par with vitamin D and omega 3s. Medical Counts have continued to accelerate throughout most of the decade, indicating very strong scientific support and a wide variety of new newsworthy research findings. Although medical and research activity has flattened since 2006, this very high level of Medical Counts will easily sustain growth for the next three to five years. Mass marketers should be capitalizing on the widespread association of protein and weight, which is still a virtually untapped opportunity. Perhaps, most compelling is the fact that protein and weight have been a highly marketable association throughout the decade and particularly before and after the low carb movement between 2003 and 2004, when low carb entered the mass-market phase temporarily at Level 1. After several years of fad-like behavior earlier in the decade, low carb and weight has once again returned to its rightful position in the Popularization Phase, important to trendy specialty/health food channel shoppers and to very health and condition-specific shoppers. Low carb has never crossed the Medical Threshold, indicating the beginning of a long-term sustainable trend and thus, continues to remain among the trendy diet fads. Specialty retailers should continue to capitalize on low carb and weight with creative new approaches recognizing its fad-like behavior.
* Although there are many factors that go into determining consumer trends, measuring how medical/nutrition activity levels have risen over the past decade, as well as some of the key milestones that have occurred and how these issues have been understood and embraced by the public are essential in predicting the sustainability of the Consumer trend line.
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Industry News
only the first 6 months after the entry into force (May 26, 2011) of this Regulation. This means by the end of November this year it will be illegal to use this health claim.
Tate & Lyle Forms Monk Fruit Partnership with BioVittoria U.K.-based Tate & Lyle has entered into a five-year strategic partnership agreement with New Zealand-based BioVittoria Ltd. for
Growth Opportunities • 54% of adults tried to lose weight in 2010 (Calorie Control Council Consumer Survey). • The typical dieter now makes four weight loss attempts per year, the highest number in 15 years (Marketdata Enterprises). • 80% of “dieters” and 69% of the general population believe it is important to consume more protein when trying to lose weight (Gallup). • 68% of consumers believe protein helps build muscle, 40% helps you to feel full, and 37% helps with general weight loss (International Food Information Council, “2010 Food & Health Survey”). • Among the 13% of food shoppers who were on a specific diet program, 11% were on the Atkins diet in 2010, 14% a low carb diet of their own (FMI, “US Grocery Shopper Trends,” 2010). • 38% of consumers chose foods/beverages because they’re high in protein; 31% said they maintained a high protein/low carb diet in 2010 (HealthFocus). • Only 2% of consumers believe calories from protein are most likely to cause weight gain. • Weight control and cholesterol tie for the most desirable benefits of functional foods; one-third of consumers bought a functional food for weight loss in 2009 (Mintel “US-Functional Food Report, 2009”). Functional Foods More than half of dieters—and 39% of the general population—are making a strong effort to increase their protein intake, according to Gallup. Of the 80% of weight watchers in 2010 on a do-it-yourself program, 60% want to use regular grocery store foods to help control their weight, reports Marketdata Enterprises. With breakfast considered the most important meal by dieters, ready-to-eat cereals, smoothies and other traditional fare are strong candidates for higher protein options. Snacks and combination products for those concerned about heart health and weight are other important options. With the American Heart Association and other organizations still negative on high protein diets, manufacturers must pay strict attention to a product’s fat content and should fortify these products to stem challenges that high protein products prevent the delivery of certain nutrients. Dietary Supplements With nearly 28 million U.S. households having a member that is obese, SymphonyIRI’s November 2010 “OTC Medication Report” estimates their annual market potential alone for OTC and supplement weight related products at $4 billion per year.
June 2011
the exclusive global marketing and distribution rights of BioVittoria’s monk fruit. Tate & Lyle will be marketing the products in the U.S. under the brand name Purefruit. According to terms of the agreement, BioVit-
Weight loss meal replacements remain a strong direction, posting sales gains for the last six years in a row to $2.4 billion in 2010 (NBJ, Feb. 2011). Cross marketing these products with energy, satiety, fortification with nutrients lost when trying to lose weight or a toning/flab fighting program are other big ideas more specific to the supplement market. Lastly, with pill form supplement sales unchanged since 2003 at $1.57 billion, designer and unique blends of protein may well be a bright light as the pill form supplement market moves away from thermogenic weight loss. References furnished upon request. About the author: Dr. A. Elizabeth Sloan is president of Sloan Trends, Inc., Escondido, CA, which is a consulting firm that offers trendtracking and predictions, strategic counsel and business-building ideas for food, supplement and pharmaceutical marketers. Each month she will provide analysis and discuss opportunities of a particular market being covered in a given issue.
SLOAN TRENDS’ TRENDSENSE is a 15-year-old trend tracking system, which identifies and quantifies trends as well as predicts the optimal timing, sustainability and life-cycle stage of ingredients, terms, product opportunities and related market issues. The model displays medical and consumer “activity levels” based on a comprehensive analysis of five critical sources of information— consumer, trade and competitive, legal and regulatory and media coverage. The resulting charts give insight into the market’s changing health issues and concerns, the ingredients that are up-and-coming and those that have just about run their course, as well as what health claims, marketing messages and products will bring your company the most success. • Emerging Phase = Trends begin to appear on the radar screen. Companies should begin to collect literature and market details for those that exhibit continual growth and that might be of interest. • Popularization Phase = Medical/Nutrition crossover to consumer media and marketplace; opportunity for niche or specialty markets. Marketers/manufacturers should begin a detailed evaluation of the supporting marketing and scientific data and determine if this term/trend offers a good strategic fit and is appropriate to pursue. Appropriate product development procedures should be undertaken. • Commercialization Phase = Mass-market ready. Mainstream consumers have a significant degree of familiarity with the term/trend and there is opportunity for competitive advantage by getting out ahead of the competition or by providing a unique and highly innovative product positioning for success.
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Industry News
toria will award exclusive global sales and distribution rights to Tate & Lyle for its monk fruit extract. Tate & Lyle will support the development of the Purefruit line with sales, research, marketing and product development. Using proprietary, natural methods, the Tate & Lyle research team has further refined and improved the taste of its Purefruit products for a wide array of commercial uses. BioVittoria will continue management of the monk fruit extract supply chain, including seedling cultivation, the grower network and natural processing.
Lonza Set to Enter Probiotic Market Lonza, Basel, Switzerland, has signed an exclusive license agreement with Berlin, Germany-based OrganoBalance for the global development, production and commercialization of products containing a probiotic Lactobacillus strain. Developed by OrganoBalance GmbH via a fermentation process, the probiotic strain acts against Helicobacter pylori (H. pylori). Research shows that H. pylori has been implicated as a common cause of peptic ulcers and gastritis. Utilizing a unique patent-protected mode of action, Lactobacillus anti-H. pylori binds to H. pylori in the stomach, thus creating large aggregates, which are subsequently flushed out of the stomach and excreted.
Ocean Spray Partners with Artemis Lakeville-Middleboro, MA-based Ocean Spray Ingredient Technology Group (ITG) and Artemis International, Fort Wayne, IN, have formed a strategic partnership through which Artemis will provide sales and mar-
keting support to Ocean Spray’s sale of cranberry powder and extract to nutraceutical manufacturers. “We are thrilled that Artemis has agreed to team with Ocean Spray to combine product expertise and industry acumen to compete in the nutraceutical market,” said Tom Jones, senior manager, Business Development, Ocean Spray ITG. “Artemis will play an essential role in supporting our existing customers and driving Ocean Spray’s continued growth in this segment.”
SIDI Working Group Comments on FSMA The Standardized Information on Dietary Ingredients (SIDI) Working Group, composed of dietary supplement firms and industry trade associations, recently submitted comments to FDA regarding the Food Safety Modernization Act (FSMA): “Title III—A New Paradigm for Importers.”SIDI supports establishing a strong program for qualifying raw material suppliers, testing incoming ingredients and verifying the contents of finished products in order to reduce the risks of contamination, adulteration and other supply chain failures. “As the global supply chain becomes more complex, proper supply chain management is critical,”the group said.“A robust testing program must be balanced with knowledge of the ingredient suppliers’quality practices. The Working Group’s guidelines emphasize a science- and risk-based approach to supplier qualification and ingredient testing. Those developing the guidelines trust that science- and risk-based principles will also be the foundation for future guidance and rulemaking related to the
Patents
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India-based Natural Remedies Pvt. Ltd. has obtained Australian patent (No. 2007257480) for its brain health ingredient, BacoMind, a standardized extract of bacopa. Published clinical research indicates efficacy and safety of BacoMind, which is designed to promote attention and memory in elders and enhance learning performance in children. Verdure Sciences, Noblesville, IN, has obtained two new patents from the U.S. Patent and Trademark Office covering the composition and methodology of its POMELLA pomegranate extract. U.S. Patents #7,897,791 and #7,919,636, granted in 2011, are in addition to U.S. Patent #7,638,640 secured by Verdure Sciences in 2009.
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June 2011
Industry News
Food Safety Modernization Act.” SIDI offered documents it has developed related to guidelines for supplier qualification, including the SIDI Protocol—a volun-
tary guideline to standardize exchange of relevant and required information between dietary component suppliers and dietary supplement manufacturers—as well as a
NIH Unveils New CAM Resource for Healthcare Providers Dialogue between providers and patients lacking despite widespread use. A new online resource designed to give healthcare providers easy access to evidence-based information on complementary and alternative medicine (CAM), has been revealed by the National Center for Complementary and Alternative Medicine (NCCAM) of the National Institutes of Health (NIH). With this new resource, providers can learn about various CAM practices and products and be better
Certificate of Analysis Guideline for Dietary Supplement Components. “We feel that the science- and riskbased principles that underpin the Work-
The NIH resource comes at a time when a survey from AARP and NCCAM indicates Americans over the age of 50 often do not discuss CAM use with their healthcare providers, despite growing frequency of use. Overall, 53% of respondents reported they had used CAM at some point in their lives. Among those, 58% said they had discussed CAM with a healthcare provider. This dialogue is important because, while CAM is a part of health and wellness for many Americans, some CAM products can interact with conventional medicine. Use of CAM among the 50 and older population is widespread. The 2007 National Health Interview Survey found that 44% of people age 50-59 use some form of CAM, compared to the average
able to discuss the safety and effectiveness of complementary and adult use rate of 38%. “Older Americans want to lead healthy, acalternative medicine with their patients. tive lives, and that means using healthcare safely,” said Elinor GinThe portal on the NCCAM website, nccam.nih.gov, is tailored to zler, AARP vice president. “For many people, CAM is an important fit the needs of all healthcare providers, inpart of staying healthy, but some CAM prodcluding physicians, nurses and nurse practiucts may make conventional medicines less tioners, physician assistants and CAM effective or lead to potentially dangerous inproviders. It includes information on the teractions. Healthcare providers and patients safety and efficacy of a range of common need to start talking together to ensure you health practices that lie outside mainstream get the full benefit of both CAM and your medicine—natural products, such as dietary medications.” supplements, herbs and probiotics, as well as Other findings from the AARP/NCCAM surmind-body practices such as meditation, chivey suggest that if CAM is discussed at a ropractic, acupuncture and massage. medical appointment, it is most likely to be Patients often don’t discuss CAM with their This resource was developed based on a brought up by the patient. Respondents were healthcare providers because (1) the provider series of NCCAM-sponsored focus groups twice as likely to say they raised the topic never asks (42%) and (2) the patients did not where healthcare providers identified the rather than their healthcare provider. Accordknow they should bring it up (30%). need for an evidence-based, one-stop place ing to the survey, the two main reasons that to answer their patients’ questions on CAM. the patients gave for a lack of discussion with With this need in mind, NCCAM developed a resource that provides their healthcare providers are that the provider never asks (42%) reliable, objective and evidenced-based information on CAM, inand the patients did not know they should bring it up (30%). In the cluding: links to relevant clinical practice guidelines; safety and efsurvey, the most frequently cited reasons for using CAM are for fectiveness information; links to systematic reviews; summaries of general wellness (77%), to help reduce pain or treat a painful condiresearch studies; scientific literature searches; programs for contintion (73%), to treat a specific health condition (59%) and to suppleuing education credit; and patient fact sheets. ment conventional medicine (53%). Those surveyed were allowed Annually, Americans spend nearly $34 billion out-of-pocket on to provide more than one reason for using CAM. CAM products and practices. Surveys show that nearly 40% of “In this survey, we found that 37% of respondents have used an American adults and 12% of American children use some form of herbal product or dietary supplement in the past 12 months. Some CAM. Other surveys show that patients do not regularly discuss of these natural products can interact with conventional treatthese practices with their healthcare providers. “NCCAM is charged ments,” said Dr. Briggs. “As we’ve learned from NCCAM-funded reto study and provide evidence-based information on the safety and search into herbal and dietary supplements, natural does not efficacy of CAM health practices that are readily available and alalways mean safe. Thus, an open dialogue about CAM use, particuready used by a great number of people,” said Josephine Briggs, larly herbals and dietary supplements, is vital to ensuring safe and MD, director of NCCAM. “As a physician, I understand the need to coordinated care.” have easily accessible and accurate information on all health pracThe AARP/NCCAM survey was conducted by telephone intertices. This web resource is a way for NCCAM to share this valuable view in October 2010, with a random sample of 1013 people age 50 information with all providers.” and older.
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Industry News
ing Group voluntary guidelines should serve as a basis for guidelines and regulations that arise from the FSMA,”the group said. “In addition, given that dietary supplements are addressed in other regulations and legislation, the Working Group encourages FDA to exempt dietary supplements from import certification. We support the agency’s effort to establish accredited third party auditors, which will further the Working Group’s efforts to ensure supply chain integrity.”
New Book Offers Natural Strategies to Reverse Food Allergies Food allergies and food intolerances are increasing dramatically throughout the world, especially among developed countries. For example, peanut and tree nut allergies among American children more than tripled between 1997 and 2008. In Britain, hospitalizations for food allergies have increased five times in the 15 years between 1990 and 2005. Furthermore, hos-
Most Women Need Help Achieving Wellness Studies indicate women require more support to stay healthy and cope with arthritis. More than 25% of American women are focused on and proactive about their health and well-being, according to the “Life…supplemented” My Wellness Scorecard National Study. In addition, nearly three-quarters of American women try to live a healthy lifestyle, but often miss the mark. Ranked on a scale from “AlphaWELL” (those who are extremely proactive and meticulous about their health) to “OhWELL” (those who do little to nothing about maintaining their health), participants were evaluated on their overall wellness regimen—maintaining a healthy diet, taking supplements, getting routine exercise and other general lifestyle habits. Only 1% of women are AlphaWELLs and 26% are WELLs, while 42% and 31% are WannabeWELLs and OhWELLs, respectively. The study suggests that while women want to be well, they need help to achieve their goals. “The average woman wears so many ‘hats’ that she often neglects taking adequate time for herself,” said Cheryl Forberg, RD, registered dietitian for “The Biggest Loser” and consultant to the “Life…supplemented” campaign. “Women need to invest in themselves. If they spend just a little time evaluating their overall well-being, it is easy to develop healthy habits that can last a lifetime.” According to the My Wellness Scorecard National Study, 58% of women report doing a fairly good job of avoiding processed foods, watching what they eat when it comes to cholesterol-rich dishes and avoiding fatty foods like whole milk and fatty meat. However, nearly 35% admit they eat more cholesterol-rich and fatty foods than they should. When it comes to vitamins and other dietary supplements, 61% of women take a multivitamin. However, only 46% of women say they take a multivitamin daily. Regular exercise is extremely important, and 48% of women say they “enjoy cardiovascular exercise like running, walking, aerobics, dancing, tennis and basketball.” However, 41% of women say they don’t have a regular exercise regimen.
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pitalizations for anaphylaxis due to food allergies have risen nearly 9% per year in recent years among developed countries. What is causing this dramatic increase in food allergies? What can be done to prevent them? More importantly, can a person with food allergies or food intolerances do anything to reverse them? Drawing from more than 1000 peer-reviewed studies, including hundreds of clinical studies, as well as clinical experience in traditional medicine, Natural Solutions for Food Allergies
Another recent survey found that women are also struggling to cope with arthritis and often feel they receive less support than their spouses. In addition, co-workers offer more support than family members. These findings came from Flexcin International, Inc., Fort Myers, FL, manufacturer of degenerative joint supplements for people and pets. A proceeds sponsor of the Arthritis Foundation, Flexcin sought to understand the level of The average woman wears so awareness and support from the many ‘hats’ that she often network of friends and family of neglects taking adequate someone living with arthritis. time for herself. The company’s research division conducted a national online survey throughout April and received responses from 1350 people who all have some form of arthritis—e.g., osteoarthritis, psoriatic arthritis, rheumatoid arthritis, gout, lupus—or other joint-related pain, illness or disability. Information and feedback from the survey will be used to develop future communications and outreach programs for people with a form of arthritis. In households where only one spouse has a form of arthritis, more than 78% of women feel they receive little or no support; nearly 66% of men said they are satisfied with support. More than half of respondents still working (56%) said they feel co-workers offer a higher level of support and overall awareness compared to that of family members. About 67% of respondents said other members of the household are never or only occasionally aware of their arthritis, while about 64% of respondents said others in the household never or rarely take an interest in their daily issues with arthritis. A majority of respondents (58%) said their arthritis hurts the most when cleaning and doing household chores. “Flexcin believes a strong support network can significantly help a person coping with degenerative joints,” said Tamer Elsafy, CEO and founder of Flexcin International. “It’s important for other people to be aware of certain issues arthritis sufferers deal with on a day-to-day basis to increase the amount of support offered.”
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Industry News
and Food Intolerances by Casey Adams, PhD, provides clear and proven strategies to reverse food allergies and intolerances using inexpensive and natural methods.
Next Proteins Acquired California-based Designer Protein, LLC, has purchased certain operating assets of Next Proteins, Inc., Carlsbad, CA, including the Designer Whey Protein sports nutrition brand and line of products, according to Partnership Capital Growth, a full-service boutique investment bank that focuses on the healthy, active and sustainable living marketplace. Designer Protein is a subsidiary of Athena Wellness Brands, LLC, a newly formed company that is backed by GarMark Partners, Northwood Ventures and Stockton Road Capital. Partnership Capital Growth acted as the exclusive financial advisor to Next Proteins in the deal.
Testing Reveals Issues with Vitamin D Supplements Among 28 vitamin D supplements recently selected for independent testing, problems were found with eight products (29% of those reviewed), according to
ConsumerLab.com, White Plains, NY. Vitamin D has become one of the most popular supplements in the U.S., with sales rising from $72 million in 2006 to $429 million in 2009, according to Nutrition Business Journal, Boulder, CO. It was the fourth most popular supplement in a ConsumerLab.com survey of its readers in 2010, used by 56% of respondents. In the recent tests, ConsumerLab.com evaluated vitamin D supplements as well as those containing calcium and/or vitamin K. Results were released in three separate Product Review reports. The most common problem found by ConsumerLab.com with supplements containing vitamin D was the wrong amount of vitamins. A popular supplement for children listed 200 IU of vitamin D per two gummy bears, but actually contained 501 IU, 251% of the listed amount. A gummy product for adults listed 1000 IU of vitamin D, but contained only 317 IU, 32% of the listed amount. A liquid product listing 42 IU of vitamin D contained only 18 IU, 44% of the listed amount. A tablet listing 800 IU of vitamin D contained only 664 IU, 83% of the listed amount. And a vitamin D/vitamin K
supplement contained its listed amount of vitamin D but provided only 36.8 mcg of its listed 50 mcg of vitamin K per capsule, 74% of the listed amount. Two other products containing combinations of vitamins D and K and calcium were contaminated with lead, according to test results. Further, a vegan vitamin D product that passed laboratory tests was not approved by ConsumerLab.com because it listed potential benefits of vitamin D but failed to provide the required FDA disclaimer for such claims.
CRN Comments on Phytosterol Health Claim The Council for Responsible Nutrition (CRN), Washington, D.C., recently submitted comments to FDA regarding the agency’s proposed rule for the health claim on phytosterols and risk of coronary heart disease. Douglas MacKay, ND, vice president, Scientific & Regulatory Affairs, said CRN has concerns that FDA’s proposed action to exclude all dietary supplement products that contain free phytosterols from bearing the approved health claim does not reflect full consideration of the impact of all
Energy Drinks with Alcohol Riskier Than Alcohol Alone
tion of AmED alters neurocognitive and subjective measures of intoxication compared with the consumption of alcohol alone. Participants (n = 56) attended one session where they were ranResearchers investigate subjects ‘under the influence’ domly assigned to receive one of four doses (0.65 g/kg alcohol; and draw some important conclusions. 3.57 ml/kg energy drink, AmED; or a placebo beverage). Performance on a cued go/no-go task was used to measure the reEnergy drinks appear to alter some of the objective and subjecsponse of inhibitory and activational mechanisms of behavioral tive impairing effects of alcohol and may contribute control following dose administration. Subjective to a high-risk scenario for the drinker, according to ratings of stimulation, sedation, impairment and research published in Alcoholism: Clinical & Experilevel of intoxication were recorded. mental Research. The mix of impaired behavioral Alcohol alone impaired both inhibitory and activainhibition and enhanced stimulation is a combinational mechanisms of behavioral control, as evition that may make alcohol mixed with energy denced by increased inhibitory failures and drinks riskier than alcohol consumption alone. increased response times compared to baseline There has been a dramatic rise in the consumption performance. Coadministration of the energy drink of alcohol mixed with energy drinks (AmED) in with alcohol counteracted some of the alcohol-inyoung people, according to researchers. AmED has duced impairment of response activation, but not Mixing alcohol and energy been implicated in risky drinking practices and response inhibition. For subjective effects, alcohol drinks is a risky practice. greater accidents and injuries have been associincreased ratings of stimulation, feeling the drink, ated with consumption. Despite the increased popliking the drink, impairment and level of intoxication, ularity of these beverages (e.g., Red Bull and vodka), there is little and alcohol decreased the rating of ability to drive. Coadministralaboratory research examining how the effects of AmED differ tion of the energy drink with alcohol increased self-reported stimfrom alcohol alone. ulation, but resulted in similar ratings of the other subjective This experiment was designed to investigate if the consumpeffects as when alcohol was administered alone.
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Industry News
delivery matrices on the efficacy of dietary supplements containing free phytosterols. “In addition to tablets, soft gels and capsules, dietary supplements can be formulated as dry powders that are intended to be blended into a food or beverage prior to consumption,” he noted.“A free phytosterol powdered dietary supplement that is reconstituted into a food or liquid beverage will overcome dissolution and distribution limitations that may occur with the tablet or capsule form of free phytosterols. Spilburg, et al., 2003, demonstrated that 4-weeks’ supplementation with a powdered phytosterol that was mechanically blended into a lemonadeflavored beverage prior to consumption significantly reduced LDL cholesterol as compared to placebo. “Furthermore, Kassis, et al., 2008, demonstrated that supplementation with a free phytosterol powder that was mixed into margarine and served as a single dose with breakfast significantly lowered plasma total cholesterol and LDL cholesterol. These data suggest that the delivery matrix used for free phytosterol-containing dietary supplements influences the efficacy of the formulation and that some dietary supplements should be able to bear the health claim relating phytosterols and risk of coronary heart disease.” A closer look at disintegration time and efficacy data reveals that disintegration of the specific dietary supplement delivery matrix is an important variable that needs con-
sideration when evaluating the effect of free phytosterols, he added, noting that disintegration time has been an important variable for other FDA approved nutrition-related health claims.
DSM Acquires Carotenoids Producer Strengthening the natural carotenoids offerings of its nutrition business, The Netherlands-based Royal DSM N.V. has signed an agreement with P&R Group (Italy) to acquire Vitatene S.A.U., León, Spain, a producer of natural carotenoids. Founded in 2004, Vitatene is a leader in the production and sale of a range of high-value natural carotenoid products derived from fermentation of the fungus Blakeslea trispora. The products are sold under the brand names Betanat and Lyconat.
Standards for TCM Addressed at ISO Meeting The second plenary meeting of the International Organization for Standardization (ISO) Technical Committee (TC) 249 on Traditional Chinese Medicine (TCM) met recently in The Hague, Switzerland, with representatives from 14 countries in attendance. Michael McGuffin, president of the American Herbal Products Association (AHPA), Silver Spring, MD, served as the U.S. head of delegation. The formation of this TC 249 came about as a result of a re-
Reports Available Driven by rising consumer concerns about weight management, health related issues and the importance of healthy, functional foods, the global market for L-carnitine is forecast to reach nearly $128 million by the year 2017, according to a new report from Global Industry Analysts, Inc. (GIA). Growth in the market is also powered by other factors, such as an aging population, greater spending power and the need to look youthful and attractive through safe and natural methods. For further information: www.strategyr.com Energy drinks—the “bad boys” of the beverage world—have become a driving force behind a resurgence in the beverage market, according to market research publisher Packaged Facts. Sales of energy drinks—along with the performance of ready-todrink (RTD) teas and sports drinks—have helped the functional and natural RTD beverage market grow to $23 billion. Packaged
24 • Nutraceuticals World
quest in 2009 by the Standardization Administration of China (SAC) for ISO to address a scope described as “standardization in the field of TCM, in terms of basis, application, administration and the related technical fields, such as terminology, diagnosis and treatment methods, manipulation standards, training standards, quality standards of appliance and equipment, and production and usage standards of Chinese herbal medicines and their test methods, etc.” An initial focus of the meeting was on structural issues. Consideration was therefore given to the formation of several working groups that will be made up of experts in key areas of interest that fall under the TC 249 scope of work. Over the course of the meeting, the committee resolved to establish working groups on raw materials, manufactured products, medical equipment and informatics. Several proposals for specific areas for standardization were also considered, including projects on ginseng seeds and seedlings, on acupuncture needles and on a coding system for herbal ingredients, among others. Additional ideas for specific areas of activity will continue to be identified.
Central American & Caribbean Regulators Discuss Supplements Twenty regulators from across Central America and the Caribbean met in Costa
Facts’ “Functional and Natural Ready-to-Drink Beverages in the U.S.” report reveals that sales growth of energy drinks isn’t conjured up by counterculture or cool-hunting marketing, but instead is due to offering consumers a distinctive benefit they want and need (i.e., more energy). For further information: www.packagedfacts.com Overall sales of clinical nutrition products are rising with an aging population in the U.S. and EU as well as rising incidence of illnesses and conditions that require clinical nutrition. But sales of clinical nutrition products containing probiotics and prebiotics are outpacing sales of conventional clinical nutrition products, opening up a new market that is dominated by a handful of players, according to a recent report from Business Insights. Nearly all of the major manufacturers of enteral nutrition products—Abbott Nutrition, Danone, Fresenius Kabi and Nestlé—are currently working to expand their offerings of products containing probiotics and prebiotics. For further information: www.business-insights.com
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Industry News
Rica recently to debate evolving food supplement regulations globally, regionally and nationally. Officials, from Costa Rica, El Salvador, Guatemala, Honduras, Jamaica, Mexico, Panama, Paraguay and the Central American Economic Integration System (SIECA), many of which are in the process of developing food supplement regulations, discussed regulatory issues such as the classification, definition and safety of food supplements. Organized by the International Alliance of Dietary/Food Supplement Associations (IADSA), the workshop was an opportunity for regulators to share the challenges they face when evaluating food supplement products, according to Peter Zambetti, IADSA chair. “Many countries in the region do not have specific laws in place for food supplements, or are in the process of developing their regulations. At the workshop there was strong emphasis on the need to ensure the safety and quality of food supplements and the establishment of a system to control food supplement products on their respective markets.”
PR*Bar to Develop Team USA Performance Nutrition Bars In consultation with U.S. Olympic Committee (USOC) sports dietitians, PR Nutrition, Inc., (PR*Bar), Carlsbad, CA, will create, develop and sell a line of Team USA performance nutrition bars through
a multi-year licensing agreement. A portion of the proceeds from sales will support the training of U.S. Olympic and Paralympic athletes and hopefuls. The agreement runs through June of 2017. PR*Bar’s line of Team USA performance nutrition bars, as well as PR*Bar’s U.S. Olympic-branded nutrition bars, will be available at retail in mid-2011. This licensing agreement augments the USOC’s strategy to build a long-term, competitive licensing platform.
Fuji Expands AstaREAL Production Responding to increased demand worldwide, Fuji Chemical Industry Co., Ltd., Toyama, Japan, has expanded production capacity for AstaREAL natural astaxanthin at its wholly owned subsidiary, BioReal (Sweden) AB, in Gustavsberg, Sweden. The expansion at BioReal is in line with Fuji´s decision to focus its astaxanthin production in Sweden. The process is modular and can be expanded rapidly to accommodate the continued growth of the natural astaxanthin market. The expansion at the Swedish facility will double current production capacity.
Domino Sugar Enters Stevia Market Domino Foods, Inc., Iselin, NJ, has formed a collaborative agreement with Germany-
Recent Certifications & Approvals
World Health Store Opens New Location in Shanghai U.S.-China Health Products Association member World Health Store (WHS) has expanded its presence in China, opening its seventh location. The company celebrated the grand opening with a visit from the U.S. Embassy’s Minister of Commercial Affairs William Zarit, along with U.S. Foreign Commercial Service and Agricultural Trade Office. WHS is the first true health food store in China, offering more than 500 individual natural health products, such as dietary supplements, sports nutrition, pre-packaged organics, aromatherapy, hand-made soaps, air/water filtration systems and exercise equipment.
EPAX received Friend of the Sea certification in 2009 for its sustainable and traceable marine sourcing and production methods.
A+ Secure Packaging, LLC, LaVergne, TN, has received confirmation that its manufacturing facility is in compliance with current Good Manufacturing Practices (GMP) following completion of a two-day FDA inspection. A+ Secure Packaging is a custom contract packaging service provider for the manufacturers of pharmaceutical, OTC, nutraceutical, dietary supplement, animal health and medical device products. EPAX AS, Aalesund, Norway, has received this year’s Friend of the Sea (FOS) Award in the omega 3 category. The recognition is largely the result of EPAX’s commitment to source from approved, sustainable fisheries and its marketing and communications efforts informing customers about the importance of sustainable and traceable certification. Additionally, as part of its internal environmental initiative, EcoVision, EPAX manufactures and distributes its marine-derived oils with minimal environmental impact.
June 2011
based WILD Flavors GmbH and Chinabased Sunwin International to offer allnatural sweetener products, such as cane sugar, rice, malt and stevia, in addition to sweetening systems that can include both natural and artificial sweeteners plus sophisticated flavor modifiers. Domino Sugar and its affiliates produce and market sugar and other sweetener products through technical, engineering and manufacturing knowledge. In addition to refined cane sugar products, Domino Sugar provides brown rice syrup, evaporated cane juice, fondants, honey, invert sugar, malt, molasses, as well as flavor and texture modifiers.
Amway North America has received sports certification for three of its NUTRILITE brand products (NUTRILITE Daily Multivitamin, Concentrated Fruits and Vegetables and DOUBLE X Vitamin/Mineral/Phytonutrient) through NSF International’s Certified for Sport program. To earn certification, the three NUTRILITE products were evaluated by NSF International to verify that the information appearing on the label matched the content of the product and that no banned substances were present. Biothera, Eagan, MN, has obtained a positive scientific opinion from the European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies for Wellmune WGP as a novel food following a review of clinical and safety data. Novel food designation allows for use in foods, beverages and supplements in Europe.
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Business Insights
Spices have served several purposes throughout history. In addition to their use in flavoring food, spices have been used in cosmetics, to embalm the dead and to mask the taste of food past its prime prior to the availability of refrigeration. Ancient Egyptian papyri from 1555 BC record the use of coriander, fennel, juniper, cumin, garlic and thyme. It is reported that the Sumerians were using thyme for its health
Spices That Belong in the Medicine Chest Today’s manufacturers and suppliers are taking an interest in spices because of their health benefits. By Gregory Stephens, RD & Sheila Campbell, PhD, RD Greg Stephens, RD, is president of Windrose Partners, a company serving clients in the the dietary supplement, functional food and natural product industries. Formerly vice president of strategic consulting with The Natural Marketing Institute (NMI) and Vice President of Sales and Marketing for Nurture, Inc (OatVantage), he has 25 years of specialized expertise in the nutritional and pharmaceutical industries. His prior experience includes a progressive series of senior management positions with Abbott Nutrition (Ross Products Division of Abbott Laboratories), including development of global nutrition strategies for disease-specific growth platforms and business development for Abbott's medical foods portfolio. He can be reached at 215-860-5186; Email:
[email protected]. Sheila Campbell, PhD, RD, has practiced in the field of clinical nutrition for 30 years, including 17 years with Ross Products Division of Abbott Laboratories. She has authored more than 70 publications on scientific, clinical and medical topics and has presented 60 domestic and international lectures on health-related topics. She can be reached at
[email protected]. 26 • Nutraceuticals World
properties as early as 5000 BC, and the farmers of Mesopotamia were growing garlic as early as 3000 BC. In the 1700s and 1800s, pirates valued spices just as much as the other booty they ruthlessly plundered from trading ships on the high seas. Today, the health benefits of spices are not going unnoticed by manufacturers and suppliers. According to a report published by Research and Markets, today’s U.S. spice and extract market is estimated at $8.5 billion, with significant growth projected in the U.S. and abroad. Many see this as an opportunity to enter or further capitalize on the booming nutraceutical market. As an example, the McCormick Science Institute was formed as a research-driven organization with a mission to support scientific research and disseminate information on the health benefits of culinary spices and herbs to both consumers and healthcare professionals. From the end-user perspective, most consumers do not differentiate between spices and herbs. Though there are many similarities between the two, there are some important differences too. Probably the most significant is where they come from on a plant. Herbs usually come from the leafy part of a plant, while spices are www.nutraceuticalsworld.com
most often obtained from seeds, fruits, roots, bark or some other vegetative substance. Interestingly, some plants yield both an herb and a spice. For instance, cilantro is the leafy herb of the same plant that gives us the coriander seed, a popular spice. Though herbs have been used more frequently than spices in the medical field, many spices do more than impart flavor. Spices are increasingly taking on more value as science and technology reveals their medicinal qualities, many of which are already well known and appreciated in Traditional Chinese Medicine, Ayurvedic food practices and other disciplines. Fortunately, spices don’t add much weight to the dinner plate aside from evocative and exotic flavors. However, in terms of therapeutic quality, mounting evidence shows that many pack a powerful punch. Spices Primarily Function as Antioxidants The healthful effects of antioxidants in reducing inflammation are recognized by experts and the public. By way of a quick review, here is a summary of what an antioxidant is, chemically speaking, and how it helps reduce inflammation. Antioxidants help neutralize or eliminate free radicals, which are unstable molecules that arise normally during metabolism, as well as from environmental influences such as pollution, radiation, cigarette smoke, herbicides and even physical exercise. To be clear, not all free radicals are bad. For example, the body’s immune cells purposefully create them to destroy viruses and bacteria. Harmful effects arise because free radicals lack an electron. They “steal” an electron from a neighboring atom, causing it in turn to become unstable. The resulting chain reaction wreaks havoc in cells and tissues. June 2011
Business Insights
As shown in Figure 1, antioxidants neutralize free radicals by donating an electron without becoming unstable themselves. Normally the body adequately defends itself against these free radicals, except when its supply of antioxidants is inadequate, or when free radical production is excessive. The negative effects of free radicals result in cell damage, dysfunction and death, impaired immunity, and contribute to chronic diseases such as heart disease, diabetes and cancer. The damage caused by free radicals also figures heavily in theories explaining the physical effects of aging. The oxygen radical absorbance capacity (ORAC) assay is a well-known method for assessing antioxidant capacity. However, measuring the antioxidant capacity of compounds is challenging. For example, there are at least three other methods besides the ORAC assay for assessing antioxidant capacity—and unfortunately results derived from using these do not always agree with one another. Spices and herbs grown in different geographies have differing antioxidant capacities. There can even be seasonal variations within the same plant. Furthermore, different parts of the plant and whether the herb or spice is dried or fresh affects its antioxidant capacity. These confounders make establishing a standard value for the antioxidant capacity of a given herb or spice difficult. Nonetheless, it is possible to provide
Figure 1: Antioxidant Behavior examples of herbs and spices that studies have identified as being particularly high in antioxidant capacity (see Table 1). Spices have been found to reduce inflammation via mechanisms in addition to their function as antioxidants. Some spices contain bioactive compounds that regulate the inflammatory and immune response. Reducing inflammation is as-
Table 1: Selected Spices & Herbs with High Antioxidant Capacity Spice
Herb (fresh)
Cinnamon
Dill
Cloves
Marforam
Cumin
Oregano
Ginger
Peppermint
Oregano
Rosemary
Turmeric
Sage
Source: Carlson MH, et al. Nutr J. 2010;9:3-11. Dragland S, et al. J Nutr. 2003;133:12861289. Halvorsen BL, et al. Am J Clin Nutr. 2006;84:95-135. Ninfali P, et al. Br J Nutr. 2005;93:257-266. June 2011
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sociated with cancers of the breast, colon, lung, pancreas and the head and neck. Spices, herbs and their bioactive compounds can also affect metabolic pathways that regulate cell division, cell proliferation and detoxification—actions important to cancer prevention. Spices also have antimicrobial and antifungal qualities. These qualities may potentially reduce cancer risk and help prevent food borne illnesses. More research is needed to support these theories; however, it is noteworthy that countries with warmer climates regularly feature the use of multiple spices in their cuisine that may act in concert or singly as antibacterial agents. Such condiments include chili peppers, garlic, onion, anise, cinnamon, coriander, cumin, ginger, lemongrass and turmeric. Each day scientists are uncovering more health effects and elucidating the mechanisms of action of several spices from around the world. Previously exotic spices are becoming commonplace as well-read consumers expect them in the marketplace. This opportunity should not go unnoticed NW by the savvy business professional. Nutraceuticals World • 27
Capitol Comments
With the world’s sixth largest economy, California is a huge market for food, drugs, dietary supplements, medical devices and cosmetics. At the same time, it is where manufacturers and sellers of such products face a formidable source of litigation known as California’s Safe Drinking Water and Toxic Enforcement Act of 1986 (“Proposition 65”), which requires companies to provide “clear and
Prop 65 Primer Knowing all the details surrounding Prop 65 could help your business avoid the pitfalls of non-compliance.
By Todd Harrison & Seung-Hyun Ryu
Todd Harrison is partner with Venable, which is located in Washington, D.C. He advises food and drug companies on a variety of FDA and FTC matters, with an emphasis on dietary supplement, functional food, biotech, legislative, adulteration, labeling and advertising issues. He can be reached at 575 7th St. NW, Washington, D.C. 20004; Telephone: 202-344-4724; Email:
[email protected]. 28 • Nutraceuticals World
reasonable” warnings to consumers if a product exposes them to a chemical known to the state of California to cause cancer, birth defects or other reproductive harm in excess of the maximum daily exposure level (a “safe harbor” level) established by California’s Office of Environmental Health Hazard Assessment (OEHHA). Proposition 65 applies to all products distributed in California and covers both in-state and out-of-state businesses that sell products or provide services to California consumers. As such, its reach extends well beyond California. Proposition 65 Warning Requirement Proposition 65 does not restrict the amount of the listed chemicals in consumer products. Instead, it only requires that a product containing any of these chemicals be accompanied by a “clear and reasonable warning.” The standard language reads: “WARNING: This product contains a chemical known to the State of California to cause cancer and birth defects or other reproductive harm.” Proposition 65 Incentives for Plaintiffs & Dilemma for Food And Drug Manufacturers Proposition 65 allows for both injuncwww.nutraceuticalsworld.com
tive relief and civil penalties of up to $2500 per violation per day. Its significance is reinforced by the fact that Proposition 65 allows any individual acting in the public interest to file lawsuits to enforce its provisions and provides 25% of the civil penalties assessed to be paid to the plaintiff, with the rest going to the State of California. Successful plaintiffs can also recover attorneys’ fees. As a California Appellate Court has noted, bringing a Proposition 65 lawsuit is “so absurdly easy.” Proposition 65 does not require a plaintiff to allege that anyone has been harmed by the product in question or that the product is defective. Instead, a plaintiff simply needs to show that one of more than 900 listed chemicals is present—in any amount—in a product, and the burden of proof is on the defendant to establish that the exposure at issue did not require a warning. There is strong pressure for defendants to settle because proving an exemption is often difficult and cost prohibitive. Not surprisingly, there are many bounty hunters who have aggressively filed thousands of Proposition 65 claims against manufacturers, distributors and retailers sometimes only for the settlement value. In fact, between 1988 and 2006 more than 25,000 businesses faced claims under Proposition 65. And in 2010 alone, 187 settlements generated roughly $13.6 million, of which approximately $7.8 million went to plaintiff’s lawyers. Questions of liability may arise between various companies in the supply chain. Under Proposition 65, any listed chemical present in the product—regardless of its ultimate origin—may trigger a warning requirement, if the amount is above its “safe harbor” level. Consequently, Proposition 65 liability may arise regardless of whether the chemical was added by the manufacturer or was present in the environment as a result of pollution. June 2011
Capitol Comments
Almost all Proposition 65 claims are settled before trial. After the settlement, products must be reformulated to remove the chemical at issue or bear Proposition 65 warnings. Where the chemical at issue is difficult to eliminate, however, food, drug and dietary supplement manufacturers/distributors face a dilemma, as the other alternative—posting a Proposition 65 warning on their food/drug/dietary supplement product—may, frankly, not be a commercially feasible option. Proposition 65 Possible Defenses & Recommendations A mere presence of one or more of the listed chemicals does not necessarily mean there is Proposition 65 liability, and there are several exemptions/defenses available to defendants who bear the burden of proof. For example, no warning is required (1) when a business has less than 10 employees; (2) when exposure to a chemical occurs at or below the “safe harbor” level, or the exposures are so low as to create no significant risk of cancer or birth defects or other reproductive harm; (3) when the listed chemical occurs naturally in food; (4) when an exposure takes place less than 12 months subsequent to the listing of the chemical by the OEHHA; and (5) when federal warning law preempts state law.
CREATING TOMORROW’S SOLUTIONS
WHAT DO YOU WANT TO STABILIZE?
“Almost all Proposition 65 claims are settled before trial. After the settlement, products must be reformulated to remove the chemical at issue or bear Proposition 65 warnings.” Proposition 65 defenses, however, are often difficult to establish. For example, to establish a “naturally occurring” defense, a defendant must prove that the chemical is, in fact, “naturally occurring” and does “not result from any known human activity” such as soil pollution or the use of pesticides. Many plaintiffs have targeted the dietary supplement industry because they know the cost of establishing “naturally occurring” levels of chemicals in soil, botanicals and minerals is extremely high and the task is quite difficult under the court cases that have addressed this issue. Nevertheless, some defendants have successfully made this argument and prevailed against Proposition 65 claims. Manufacturers and sellers of food, drug and dietary supplement products should consult with an attorney before deciding whether and how to provide Proposition 65 warnings in California. When companies receive a Proposition 65 60-day Notice of Violation, they should immediately contact an experienced deNW fense lawyer to strategize their options. June 2011
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Nutraceuticals World • 29
Eurotrends
Inflammation is a process that periodically occurs in the body, usually connected to some sort of infection that needs to be fought. This makes shortterm inflammation, by and large, a good thing, which is typically over with once the job is done. Chronic inflammation, however, is another story.
Chronic Inflammation Pursuing biomarkers of inflammation might create new stories for old nutrients.
By Joerg Gruenwald
Dr. Joerg Gruenwald is president of analyze & realize ag, a specialized business consulting company and contract research organization (CRO) in the fields of nutraceuticals, dietary supplements, herbals and functional food. He is also the author of the PDR for Herbal Medicines. He can be reached at analyze & realize ag, Waldseeweg 6, 13467 Berlin, Germany; 49-3040008100; Fax: 49-30-40008500; E-mail:
[email protected]; Website: www.analyze-realize.com. 30 • Nutraceuticals World
In 2004, Italian researchers published a review that stated: “Obesity, insulin resistance, and diabetes are associated with a pro-inflammatory state, which in turn is associated with increased cardiovascular risk.”This pro-inflammatory state is more popularly referred to as “chronic inflammation”—and it has since been linked to a range of conditions promoting heart disease, osteoporosis, cognitive decline (up to and including dementia), Type 2 diabetes and arthritis. Researchers believe that chronic inflammation is a modern condition, brought about—like many other ailments—by unhealthy diets combined with physical inactivity, sending the usually-temporary inflammation process into an endless loop. Several biomarkers connected to inflammation have been identified, clearing the path toward the detection of, and clinical research into, chronic inflammation. Obesity, for example, has been shown to increase inflammatory markers, indicating higher risk for heart disease and other conditions. Indeed, being overweight is not just a cosmetic issue; rather it promotes serious biochemical changes www.nutraceuticalsworld.com
that can lead to other, more serious health issues. A Potential Solution? Meanwhile, scientists in the Netherlands recently formulated a test supplement designed to counteract chronic inflammation by initiating metabolic changes in overweight people. The test supplement—consisting of fish oil, green tea extract, resveratrol, vitamins C and E and a lycopene-rich tomato extract—produced changes in genes associated with inflammation, counteracting some of the effects of obesity. The underlying mechanism is called nutrigenomics, or the effect certain nutrients can have on an individual’s gene expression. Inflammation is a cascading process that involves pro-inflammatory mRNA and cytokines/chemokines, and the expression of their underlying genes can be affected by certain nutrients. Thus, consuming anti-inflammatory nutrients can, in fact, reduce the severity of the inflammatory cascade. Another interesting aspect of chronic inflammation and the fact that it may be at the center of several serious health conditions is this: What if heart disease, Alzheimer’s, colon cancer and many other conditions are merely symptoms of inflammation? Wouldn’t it be nice, by “curing” the chronic inflammation, to cure all those diseases along with it? One cure for multiple illnesses! A theory like this might even be intriguing enough to make the healthcare profession, which is traditionally skeptical of healthy foods, take notice of the ever-growing number of ingredients targeting inflammation. In fact, the consumption of antioxidants as anti-inflammatory ingredients is already being considered a potential strategy for the reversal of disease progression for many June 2011
Eurotrends
conditions where inflammatory markers play a starring role. Not surprisingly, most anti-inflammatory nutrients have antioxidant properties—because free radicals are linked to inflammatory states—and are fairly well known as such to the consumer. Among them are herbal extracts, such as ginger, turmeric, boswellia and green tea, as well as Pycnogenol, astaxanthin, resveratrol, omega 3 fatty acids, vitamins C and D, folic acid, CoQ10, chromium and L-carnitine. And coincidentally, all of these ingredients could use new stories. In addition, the so-called superfruits (specifically açai and pomegranate) are also being discussed as having potential anti-inflammatory power, with studies already published. Some questions to consider: How easily can consumers understand inflammation, as well as the connection between inflammation and, say, Alzheimer’s? Will they believe that an anti-inflammatory nutrient (e.g., a lycopene-rich tomato extract) can help?
June 2011
“…the consumption of antioxidants and anti-inflammatory ingredients is already being considered a potential strategy for the reversal of disease progression for many conditions where inflammatory markers play a starring role.” At first glance, the connection between chronic inflammation and several serious health conditions is a better selling argument than merely being an antioxidant, which, to the consumer, amounts to nothing more than “good for you” at this time. However, time will tell if this bears out. According to industry insiders, it all depends on how the next generation of dietary supplements or functional/med-
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ical foods is marketed. All of this is good news for the functional/medical food and dietary supplement industries, which continue to struggle in Europe in the wake of the new Health Claim Directive. Now all that remains is a successful health claim application using an anti-inflammatory ingredient and a study with inflammatory NW markers to send a signal.
Nutraceuticals World • 31
Quality Focus
My last column (April 2011) was a tough one to write, however the process of stepping back shook cobwebs off some interdisciplinary synapses and got me thinking about aspects of quality beyond those involving analytical chemistry—in particular, the roles of knowledge and ignorance in supply chain management and how these pertain to quality. I’ll con-
Supply Chain Management: Like Laundry, It Never Ends... Supply chain management needs to be more than a laundry list of what you should know and what you should control.
By Paula Brown
Paula Brown has supported the natural health and food industry for more than a decade by conducting applied research on product quality, safety and efficacy. Ms. Brown was appointed Fellow of the AOAC in 2009 after serving five years as General Referee, six years on the Dietary Supplement Task Force, participating on seven Expert Review Panels, and directing three collaborative studies. She sits on the American Botanical Council Advisory Committee, the Natural Health Products Program Advisory Committee for Health Canada, grant review committees for NCCAM, and Chairs NSF’s Joint Committee for Dietary Supplements. She is the director, Integrative Bioscience Research Cluster, at the British Columbia Institute of Technology. She can be reached at
[email protected]; Website: www.bcit.ca/appliedresearch/ibrc/. 32 • Nutraceuticals World
centrate on the three P’s for now: Provenance, Processing & Production. Take a minute and think about everything these three terms imply—all movement and storage of raw materials, in-process materials and finished products from manufacture through to the consumer. Consider the level of knowledge and detail you actually need to have about all of these elements to ensure a high quality product is delivered. In analytical science, we know that every measure or variable (such as weighing, pipetting, loss during transfer, etc.) has uncertainty associated with it, and these errors propagate. Add enough steps to any process and even very small errors associated with each can accumulate in a hurry. In a previous column, the SIDI protocol (Standardized Information on Dietary Ingredients) was introduced (“Quality Focus,” November 2009). To recap, it provides a checklist for purchasers to use when sourcing raw materials. The template for botanicals includes a section called “Botanical Manufacturing Information” with places to enter the name and address of the manwww.nutraceuticalsworld.com
ufacturer, the mode of manufacturing, agricultural process, manufacturing process, GMP compliance sterilization or fumigation method, and known or potential sources of impurities and/or contaminants. The agricultural process section gives guidance on what sorts of information to enter, such as method(s) of cultivation (e.g., sustainably-wildcrafted or cultivation method), identification, harvest, handling and post-harvest processing. In order to manage the supply chain, the SIDI checklist would have to be filled out each time the material changes hands. The provenance of the material would be tracked by a form from the collector or farmer and a form from for the purchasing center that buys and compiles material from small farms/collectors. Throughout the processing there would be forms—from the facility that processes material, ships the material, extracts material, the bulk packager, maybe another shipper. After all these stages the dietary supplement ingredient goes into production and there could be more forms for the finished product manufacturer, packager, labeler and distributor. While there may be fewer or more steps, the point is there are numerous steps requiring documents to trace materials from field to finished product. As a manufacturer, perhaps you will see a single checklist from the raw material supplier and one would hope it reflects the information from all the other checklists that have been accumulating. The intent here isn’t to suggest we print redundant certificates but rather to point out the level of detail that can exist for every stage of every component in a finished product, despite whether the information is known or not. Rather than blather on about forms and how “what we don’t know may in fact hurt us,” let’s consider an example or two... June 2011
Quality Focus
Provenance The SIDI form gives the supplier the opportunity to determine whether the material was wild collected or cultivated, as well as the place (country, farm, GPS coordinates) from which it was collected. The geographic origins of a material can provide volumes of information over and above simply knowing where something was grown. There can be tremendous implications to quality through informing manufacturers about the likelihood of a particular contaminant, such as the use of DDT to combat malaria in some countries. USDA’s Animal and Plant Health Inspection Service (APHIS) can and will stop botanical raw material at the border if it comes from a country that is known to harbor a plant pathogen, while the same material from a non-infested country is allowed. Processing Processing and preservation techniques vary from supplier to supplier. Simple drying of materials can range from lying out in the sun, wood or charcoal fires to a temperature-controlled vacuum oven. Knowing how a material was dried is critical information when considering potential risk associated with that material. For example, sun-dried materials in warm climates may be at risk for mold growth on wet biomass. Molding of root materials, such as ginseng, can lead to unacceptable levels of mycotoxins. Biomass dried with the assistance of open fire may cause the material to be high in potentially cancer-causing polyaromatic hydrocarbons (PAH). Production Botanicals (and other dietary supplement ingredients) can be contaminated or otherwise sullied by the manufacturing process just as easily as in any other part of the supply chain. Many sensory and/or pharmacologically relevant compounds can be degraded with light, heat or even changes in pH. Spray-drying an extract for too long or at too high a temperature could turn a nice, aromatic, light-gray green material into a charred mess. Even an over zealous tablet compression could generate enough heat to decrease the quality of a finished product. The selection of the excipients could also lead to contamination and impact quality. Summary This column was not intended to be a laundry list of areas that can introduce risk and potentially decrease product quality. Obviously we cannot know everything and we cannot control everything. But making decisions throughout the supply chain to allocate resources based on potential risk is just good business management. That being said, just identifying risks seems to lead back to a massive laundry list that gets longer and longer with the number of components, ingredients and products a company deals with in manufacture. Perhaps more significant than all the potential sources of risk in a supply chain are the consequences of failures. I believe FDA has made it clear where it feels the consequence of failure poses too great a risk through NW enactment of the 100% Identity Rule. June 2011
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Nutraceuticals World • 33
The Research Process
Can a company design a study for a condition-specific product and still be in compliance with the Dietary Supplement Health & Education Act (DSHEA) and subsequent laws? By law, as most people know, dietary supplements cannot be marketed to treat, prevent or cure any disease, which is why FDA requires that the following statement be listed on all dietary
Research At Your Own Risk Navigating the complex world of dietary supplement research can be challenging for even the most seasoned professionals.
By Douglas Kalman, PhD, MS, RD, CCRC, FACN
Douglas Kalman, PhD, MS, RD, FACN, is director of clinical nutrition at Miami Research Associates (MRA), Miami, FL, in the Nutrition and Endocrinology Division. MRA is a clinical service organization involved for over 10 years in phase II through post market trials for the pharmaceutical and nutraceutical industries. Mr. Kalman is also an active member of the American College of Sports Medicine, American College of Nutrition, the American Dietetic Association, the National Strength and Conditioning Association and the Association of Clinical Research Professionals. He is also the executive vice president and treasurer of the International Society of Sports Nutrition (ISSN). He can be reached at 305-666-2368; Fax: 305-669-8966; E-mail:
[email protected]; Website: www.miamiresearch.com. 34 • Nutraceuticals World
supplement products: “This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease." Claims The label of a dietary supplement or food product may contain one of three types of claims: a health claim, nutrient content claim or a structure/function claim. Health claims describe a relationship between a food, food component or dietary supplement ingredient, and reducing risk of a disease or health-related condition. Nutrient content claims describe the relative amount of a nutrient or dietary substance in a product. A structure/function claim is a statement describing how a product may affect the organs or systems of the body—but it cannot mention any specific disease. Remember that to be fully DSHEA-compliant one must also submit to the FDA any structure/function claims that are going to be made within 30 days of going to market (it does not need approval; it just needs to be submitted). While one does not need FDA approval on a structure/function claim, one does www.nutraceuticalsworld.com
need substantiation for any claim that is being made. Most important, the marketing related to a supplement cannot state that it prevents or reduces the risk of a disease or health-related condition unless the claim has been approved by FDA. Conditions As Diseases If you accept the notion that conditions are related to diseases, then let’s consider that Metabolic Syndrome (“MetSyn”)—a combination of abdominal obesity, elevated blood pressure, high triglycerides, low HDL (the “good” cholesterol) and/or high blood sugar—might also be a disease. While this condition (MetSyn) is not formally recognized by FDA as a disease, many health organizations have definitions for it. Recently, two studies published in peerreviewed journals detailed the effects of a dietary supplement on bone metabolism in postmenopausal women with MetSyn. The dietary supplement contained 200 mg hop rho iso-alpha acids, 100 mg berberine sulfate trihydrate, 500 IU vitamin D(3) and 500 mcg vitamin K(1), and was taken twice daily for 14 weeks. The purpose of these studies was to evaluate the impact of a dietary supplement (“targeted phytochemicals and nutrients”) on bone turnover markers in healthy postmenopausal women and postmenopausal women with MetSyn. These studies found this specific dietary supplement produced a more favorable bone biomarker profile indicative of healthy bone metabolism (i.e., positive changes in osteocalcin, 25-hydroxyvitamin D and with type-I collagen) in healthy postmenopausal women as well as those with MetSyn. Here’s the tricky part. FDA has indicated that in order to conduct a human interventional clinical trial with a dietary supplement on a “diseased” population, an June 2011
The Research Process
“FDA has indicated that in order to conduct a human interventional clinical trial with a dietary supplement on a ‘diseased’ population an Investigational New Drug (IND) application must be filed.” Investigational New Drug (IND) application must be filed. INDs require a lot of paperwork, are laborious, and might affect opportunities to market the product as a dietary supplement. In other words, FDA says any product being studied for anything that is not quality-of-life related and where the primary endpoint is disease related (e.g., change in lipids in a group of people with elevated cholesterol outside the normal range) you need an IND. This is all well and good unless you want to take that study product to market as a supplement. A perfect case in point is the recent New Dietary Ingredient (NDI) rejection of homotaurine. FDA rejected homotaurine as a dietary ingredient because it once was submitted
June 2011
as part of an IND package for potential development as a drug. Going forward, it will be an uphill battle for the company to argue that this ingredient be considered a supplement and not a drug. In fact, it appears from the February 2011 FDA ruling on homotaurine that once an ingredient gets the FDA stamp of approval for research under the IND program, then the agency has the power to remove the product or ingredient from the supplement marketplace. The studies mentioned previously by Drs. Holick and Lamb provide some evidence that their unique intervention aids in healthy bone metabolism and has potential in those who are at increased
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osteoporotic risk. But there are still some unanswered questions: 1. Did the researchers or sponsor know they needed an IND application for their 2011 study (since it was in women with MetSyn)? 2. If they did file an IND application, can the studies be used as part of product substantiation, since the group studied had a “condition”? These are important issues to consider in designing clinical trials. While research is certainly important, one must be cognizant of the subtle details that might affect the product’s target population and marketability in NW the future. References furnished upon request.
Nutraceuticals World • 35
Soy
Story
Soy has had a wild ride during the past decade, and it’s not over. By Rebecca Wright Editor
hen Nutraceuticals World first covered the soy market in January 1999 (in only our second issue), most experts painted a pretty rosy picture. For several reasons—e.g., health appeal, formulation benefits, rising consumer awareness—soy became a media darling and a hot target for product developers and marketers. And once FDA approved a health claim linking soy to a reduction in coronary heart disease risk, it was soy’s time to shine. But like most health trends, the good times couldn’t go on forever. “Soy’s role in the marketplace has changed in recent years,” said Peter Golbitz, director of business development,
W
36 • Nutraceuticals World
Canada-based SunOpta Grains and Food Group. “Originally, it was a macro trend and a driver—every large company wanted soy as an ingredient. It wasn’t about health and wellness; it was just about soy.” “But every trend has its cycle, and now soy is becoming a mature category and is a micro trend,” Mr. Golbitz added. “Few foods created a flurry like soy did, but now the attractiveness of soy is competing with other trends under the health and wellness category—e.g., whole grains, protein, antioxidants, etc.”
The U.S. Market
soy market reached more than $4 billion in sales in the U.S. by 2004, a point at which the market started to turn. Fast forward to 2011 and it is very clear the soy market has matured. Growth has slowed or declined completely in most
This article in a nutshell: • The U.S. market • A polarizing ingredient • Soy isoflavones • The global outlook • Despite the health benefits… • Soy’s future
Buoyed by incredible momentum, the www.nutraceuticalsworld.com
June 2011
Soy
categories, leaving small pockets of opportunity in others. Focusing on the bright side, Joe Jordan, content director, Soyatech, Southwest Harbor, ME, pointed out, “While the overall industry has been stuck in neutral since 2004, it has become increasingly clear that soy foods are not monolithic. Convenient, delicious foods containing soy protein continue to find success in the marketplace. Meat alternatives and energy bars, in particular, have experienced sustained sales growth even while the larger industry has slumped.” Proving problematic for the category, recent research has not only questioned the efficacy of soy in relation to certain health issues, but also its safety, especially in relation to increasing the risk of cancer. While some experts claim these study results are unfounded, based on poorly designed trials, the negative aura surrounding soy continued to grow during the last several years. “Negative information about soyfoods, mostly in the form of vague, poorly substantiated Internet rumors, have experienced a resurgence in the last couple of years, impacting the soyfoods market strongly in 2009,” Mr. Jordan said. “More positive news in 2010, including new scientific research, has seemed to turn the tide for the time being.” Furthermore, soy is facing some stiff competition. Ironically, just as it offered consumers an alternative to dairy and meat, now other options like almond milk and fungus-based meat are moving in on soy’s territory and stealing market share. According to a new report from Chicago, IL-based Mintel (“Soy Food & Beverages U.S., March 2011”), while some of soy’s plunge can be blamed on the recession and consumers cutting back on premium-priced soy items, competition from other heart healthy foods and good-tasting, soy-free milk alternatives June 2011
kets benefit from their full range of shelfstable, frozen and refrigerated soy foods and beverages,” the market researcher said.“Furthermore, major retailers in both supermarket and mass merchandisers carry their own private label brands of soy food and beverages.” On the other side of the spectrum, natural supermarkets captured $192 million, or 7% of the soy market, after stealing one percentage point of sales from FDM stores in 2008-10. While relatively small, Mintel said it is important to keep in mind that this channel is central to the soy market, as it’s a launching pad for a broad array of soy products that, once successful, gain distribution in FDM and other outlets. Another point Mr. Browne wanted to drive home: Mintel’s latest report covered food and beverage products where soy is the primary ingredient. So he said this would exclude supplements as well as meal replacements. The latter segment, he said, is doing fairly well, so if that had been factored into the analysis the overall picture might have been affected. Still, most experts agree that soy’s best days might be behind it. “A decade ago, the soy foods market was in a period of rapid growth, featuring constant innovation from nimble, entrepreneurial companies as consumer awareness of soy exploded and as soy foods became more convenient, familiar and accessible,” said Mr. Jordan. “However, by 2004 the market of consumers willing to eat soy had become
are also challenging the industry and hampering soy sales. “Aside from the depressed economy, consumers are experiencing soy burnout,” said David Browne, senior analyst, Mintel.“Not too long ago, American consumers were told soy is a ‘superfood’ they can’t get enough of, but now they’re hearing they may be getting too much. With soy aversion now a relevant concern, there are tons of competitive products available that have made it easy to switch to something new.” Mintel/SPINS data show the soy food and beverage market declined 16% between 2008 and 2010 to $2.6 billion. And the market researcher predicts another 17% decline between 2010 and 2012 (see Table 1). While these numbers are somewhat shocking, Mr. Browne said they need some context.“When we put this most recent report out a couple of soy organizations said we were painting a poor picture of the market. But it is important to realize that these numbers don’t reflect sales from Trader Joe’s, Whole Foods or Wal-Mart, and a lot of consumers shop for soy products at the these stores,” he explained. Given this variable, he said the picture could be different if those numbers were available. Further, he said, the soy market stands to perform better in the coming years when factoring them in. Mintel/SPINS data point to the FDM (food, drug and mass) channel as holding the largest share of soy sales, accounting for 93% of total soy food and beverage sales, or $2.4 billion in 2010. “Supermar-
Table 1: Sales of Soy Foods and Beverages in FDMx and Natural Supermarkets, at Current Prices, 2008-12
Year
$ million
% change
Index (2008 = 100)
Index (2010 = 100)
2008*
2,995
-
100
116
2009*
2,835
-5.3
95
110
2010*
2,588
-8.7
86
100
2011 (fore)
2,372
-8.4
79
92
2012 (fore)
2,153
-9.2
72
83
* 52 weeks ending Dec. 27, 2008; Dec. 26, 2009; and Dec. 25, 2010 Source: Mintel/SPINS/Nielsen www.nutraceuticalsworld.com
Nutraceuticals World • 37
Soy
saturated—and nearly all of the independent companies who had zealously spearheaded innovation in the category were swallowed up by large food manufacturers—and growth quickly cooled,” he continued.“Since then, the market has grown very slowly—even declining in 2009 for the first time since we began tracking the category.” Contrary to Mintel’s analysis, Soyatech’s data showed that 2010 was a year of mild recovery for the soy foods market, as overall sales grew by about 2%.
A Polarizing Ingredient Like many hot ingredient trends, there is a certain period of exploration from companies in terms of product development. When soy was the “it” ingredient companies spent a lot of time perfecting formulations, specifically trying to tackle one of its most notable attributes: the taste. Apparently, the taste issue is a polarizing one. For soy lovers, taste is the main reason they consume these products, while soy haters avoid it for the same reason. “At least half of survey respondents use soy because they like the taste. Interestingly, taste is also the main reason non-soy users steer clear of soy (45%),” Mintel said in its report. Soyatech’s Mr. Jordan offered a similar view. “U.S. consumers generally identify soy as a healthful food. However, taste issues and concerns over the possibility of negative health implications continue to depress market growth, and we believe they will continue to do so in the near term,” he commented. Regardless of the sensory issues, dedicated soy companies will continue to work out the formulation kinks. “There is ongoing work to improve the flavor and color of soy protein, making it possible to use in a wide variety of products,” said David Krause, global applications manager for Israel-based Solbar, suggesting that consumers, especially Westerners, are looking for an invisible ingredient.“Soy is not something that is traditional to them; it is quite new and sometimes they are not happy with that. It seems people want the benefits of an ingredient that—in terms of taste and appearance—is not there.” 38 • Nutraceuticals World
Just as soy offered consumers an alternative to dairy and meat, now other options like almond milk and fungus-based meat are moving in on soy’s territory and stealing market share.
Perhaps ADM, Decatur, IL, has the answer. The company recently unveiled Clarisoy, an isolated soy protein that allows formulators to provide protein fortification in transparent, low pH beverage systems. “ADM’S Clarisoy is the world’s first vegetable-based protein that offers clarity and complete protein nutrition for low pH beverage systems,” commented Courtney Kingery, marketing and customer development manager, ADM Oilseed-Specialty Products. As background, in March 2011, ADM signed an agreement with Canada-based Burcon NutraScience to commercialize Clarisoy isolated soy protein. This ingredient, Ms. Kingery said, will come in handy for sports and energy beverages. “Mintel projects double-digit growth in the sport and energy markets and the fruit and vegetable drink market through 2015,” she added. Keith Parle, vice president of commercial cereal, bars & confectionery end-use markets, Kerry Ingredients & Flavours, Beloit, WI, agreed that taste is the number one consumer acceptance issue when it comes to soy. But he said the improvements on this front during the last several years have been very positive.“There has been continual development of soy masking technology and definite improvement in the last three or four years,”he said.“Just think: bars www.nutraceuticalsworld.com
were terrible 10 years ago and I think they are definitely in a different place today.” “I think flavor houses and formulators have done a great job improving products that were pretty awful and making them, from a sensory point of view, mainstream,” he added. Another positive, according to Mintel, is that soy still has health benefits compared to meat, and many more innovations currently on the market compared to other non-soy meat and dairy alternatives, so it will likely remain a household presence among many health-conscious consumers. In this vein, Mintel said, while the total market dropped more than 13% between 2008 and 2010, seven of the top 10 segments (energy bars and gels; frozen meat alternatives; condiments, dressings and marinades; refrigerated meat alternatives; cold cereals; refrigerated juices and functional drinks; and tofu) saw moderate growth, driven by demand for health and convenience, and fueled by innovation to meet these. (See Table 2, page 40.) “Soyfoods: The U.S. Market 2011,” published in April by Soyatech, also highlighted the growth in the meat alternatives and energy bar categories. The latter, it said, witnessed 18% growth in 2010 vs. 2009, while the former posted 4% growth during the same period. “Energy/nutritional bars and meat alternatives are also relatively large segments of the market that we expect to experience consistent growth over the next few years,”said Soyatech’s Mr. Jordan. “New blends of vegetable proteins that include soy are providing a basis for further flexibility and innovation in the category.” According to Mintel’s report, soy-based energy bars and gels generated $522 million in sales, representing 20% market share in 2010 in FDM and natural supermarkets. “From 2008-10, the segment grew 21% benefitting from product innovations from leading companies, including Clif Bar, which offer good tasting products targeted to specific consumer segments.” Mr. Jordan also discussed emerging opportunities for soy. “Smaller subcategories that have shown promise recently include soy-based condiments as well as frozen entrees, pizzas and convenience foods,” he said. “Soyfoods, if marketed June 2011
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Soy
properly, may gain some ground by leveraging the current success of ‘gluten-free’ foods where possible, but that will not be a long-term growth trend.” Once considered a leader in the soy segment, Mintel said baby food (18% of the soy market) sales fell 48% to $477 million between 2008 and 2010, well behind energy bars in sales. Mr. Browne cited recalls of infant formula and the aggressive encouragement of breastfeeding as major causes of the sharp decline. Refrigerated non-dairy beverages, which comprise nearly 15% of sales at $380 million, experienced a sales decline of more than 14% between 2008 and 2010. As far as other trends go, SunOpta’s Mr. Golbitz offered, “There is continued growth in fermented soy products. In the future, we believe there will be more soy products with new flavors, additional benefits and new products like soy/juice blends. The tofu market has grown, and
will continue to grow as it is made more convenient and available for consumers.” Mr. Browne believes formulators will eventually move away from using soy as the main attraction. “Product developers may be able to gain new users by blending soy ingredients with nuts and grains to create innovative, better tasting and possibly more affordable food and beverages.”
Soy Isoflavones According to Aparna Parikh, MBA, RD, senior marketing manager (for geniVida and Women’s health platform), DSM Nutritional Products, Parsippany, NJ, the isoflavone market has fluctuated over the years, even though consumer awareness of soy isoflavones and their health benefits is at 37% (Multisponsor surveys, 2010). However, she said if you look at the market for condition-specific supplements (growing as a whole), such as
menopause supplements (predominantly soy isoflavones and black cohosh) and bone health supplements, the categories have continued to grow (NBJ, 2010). “Soy isoflavones (either as a total or their individual components) are to a large extent positioned for menopausal health and increasingly for bone health— the idea being that calcium and vitamin D by themselves are not enough,” Ms. Parikh explained. “This positioning is based on sound scientific evidence that soy isoflavones and their individual components play a key role in imparting health benefits for both these areas.” Laurent Leduc, vice president, Health Division, Frutarom Americas, North Bergen, NJ, believes some of the struggles soy isoflavones have encountered during the last 10 years can be attributed to unfounded research. “The soy isoflavone market grew very rapidly to mid-2000, then saw steep decline during the past decade,” he said.
Table 2: Sales of top 10 soy food and beverages segments in FDMx and natural markets, 2008-10
2008*
2009*
2010*
Sales growth 2008-10
Share change 2008-10
$m
% market share
$m
%market share
$m
% market share
%
% points
Energy bars and gels
432.9
14.5
444.7
15.7
522.0
20.2
20.6
5.7
Baby food
921.7
30.8
801.0
28.3
477.2
18.4
-48.2
-12.3
Refrigerated non-dairy beverages
443.1
14.8
420.8
14.8
380.6
14.7
-14.1
-0.1
Frozen meat alternatives
249.7
8.3
252.8
8.9
260.0
10.0
4.1
1.7
Condiments, dressings, and marinades
118.6
4.0
124.6
4.4
130.5
5.0
10.0
1.1
Cookies and snack bars
146.8
4.9
115.9
4.1
100.1
3.9
-31.8
-1.0
Refrigerated meat alternatives
71.4
2.4
76.9
2.7
83.4
3.2
16.8
0.8
Cold cereals
77.8
2.6
67.5
2.4
78.8
3.0
1.3
0.4
Refrigerated juices and functional drinks
46.7
1.6
53.1
1.9
69.3
2.7
48.4
1.1
Tofu
61.2
2.0
61.4
2.2
62.4
2.4
2.0
0.4
2,569.9
85.8
2,418.7
85.3
2,164.3
83.6
-15.8
-2.2
425.1
14.2
415.8
14.7
423.9
16.4
-0.3
2.2
2,995.0
100.0
2,834.8
100.0
2,588.3
100.0
-13.6
-
Top 10 Segments
Subtotal All other food/beverage segments Total
* 52 weeks ending Dec. 27, 2008; Dec. 26, 2009; and Dec. 25, 2010; Source: Mintel/SPINS/Nielsen 40 • Nutraceuticals World
www.nutraceuticalsworld.com
June 2011
Soy
Mr. Leduc blamed the drop on tenuous research resulting in the negative portrayal of soy. For the future, Mr. Leduc believes greater care needs to go into designing clinical trials on soy and soy isoflavones, with a particular focus on bioavailability. “You need to test to make sure subjects are actually getting isoflavones in the bloodstream,” Mr. Leduc said.“Today researchers are doing a better job understanding the differences in absorption but there is still a long way to go.” Mr. Leduc mentioned this as a point of concern because the negative studies that impacted the market years ago did not test for the bioavailability of isoflavones. Yet, these studies still made broad (negative) conclusions about isoflavones. Fortunately, Mr. Leduc said he has noticed increased interest in soy isoflavones during the past 12 months. “We are seeing interest in soy isoflavones for both supplement and functional food applications.” As for health benefits, he said, “Menopause is still the primary use for isoflavones; secondary would be bone health (synergy with calcium); and incontinence would be the third.” In terms of the latter, Frutarom carries a product substantiated by clinical studies on bladder control. The propriety blend, called Go-Less, combines pumpkin seed extract and SoyLife.“This is a new indication area for the U.S. market,” Mr. Leduc said. “We strongly believe in the synergy of these extracts for bladder health.” Mr. Leduc also highlighted the important differences between natural and synthetic materials, especially in relation to Frutarom’s soy germ ingredient, SoyLife. SoyLife is rich in isoflavones. But more than just an isoflavone concentrate, SoyLife offers the complete spectrum of natural soy compounds. This soy matrix, Mr. Leduc said, enhances the bioavailability of the isoflavones. “You need all the components of the matrix to benefit the body. You don’t have the same synergy when you are creating synthetic isoflavones. The soy matrix is there for a reason.” Sharing his opinion on isoflavones, SunOpta’s Mr. Golbitz commented,“While I understand that isoflavones are in soyJune 2011
beans and they may be responsible for some of the health benefits, isoflavone supplements are not really a soy food, nor do I think they should be classified as a soy food per se. These are highly refined compounds that may or may not be very effective without all of the other healthful components of the soybean, particularly the protein.” Offering another view, Ms. Parikh said isoflavones in soybeans can be broken down into three principal components: genistein, daidzein and glycitein, representing approximately 50%, 40% and 10% of the total soybean isoflavone content, respectively. “Genistein, the primary isoflavone in soy foods is the main circulating isoflavone in humans and has been the most thoroughly researched of the three— in humans and animals it has been experimentally the most efficacious,” she said. “geniVida, pure genistein, is an isoflavone that has been developed by DSM for use in dietary supplements and functional foods. It is a nature-identical, non-allergenic (and hormone-free) form of genistein that was created in the laboratory, thereby guaranteeing purity and consistency.” “Studies indicate that geniVida can effectively relieve menopausal symptoms while helping to improve bone mineral composition,” Ms. Parikh continued. “In a randomized, placebo-controlled, doubleblind clinical study, geniVida supplementation resulted in a 51% reduction in hot flashes and night sweats compared to only 27% for women in a placebo group.” This new evidence, Ms. Parikh said, complements research showing that geniVida Bone Blend significantly increased bone mineral composition by up to 3.4% in postmenopausal women in comparison with women taking a calcium placebo who actually experienced bone loss.
The Global Outlook While the U.S. soy market has had its struggles, the global outlook seems a bit more upbeat, according to estimates from Global Industry Analysts (GIA), San Jose, CA, and its new report, “Soy Foods: A Global Strategic Business Report.” “Global demand for soy foods witnessed a significant increase during the past few years. Although the market witwww.nutraceuticalsworld.com
nessed 6% growth from 2006-2007, the market for soy supplements was adversely impacted by the anti-soy allegations that surfaced during that time,”the report said. “However, subsequent research and investigations rendered the allegations vague on grounds of incorrect research methodology used to come to such inferences. The soyfoods industry, thereafter, recovered from the controversies and has since been marching forward.” GIA claims the worldwide soy foods market continues to be driven by increasing consumer awareness about the health benefits, including heart health, bone health and protection from cancer. “In addition to its high protein and fiber content, soyfoods provide low concentration of saturated fat, and are completely without cholesterol,” the report said. “Soyfoods have now emerged as a healthier and convenient dietary alternative in developed nations. Even in developing markets, soyfoods have found a place in the mainstream market and are provided as packaged foods in several varieties.” Asia-Pacific represents the largest regional market for soy foods worldwide, according to GIA, with the U.S. trailing behind, followed by the European market. “Future market growth is expected to be driven by developing regional markets such as Asia-Pacific and Latin America,” the market research firm said. “The shift of soy foods from small-sized natural food outlets to mainstream markets in developing countries could be attributed to market liberalization and improved supply network,”GIA reported.“The market for soy-based products expanded considerably with innovative and continuous launch of various soy products. Formerly, soy products found in retail stores were limited to tofu, bitter-tasting soymilk and poorly textured meat analogues. With advanced technology, development of tasty soy products has become easier. Several types of tasty soy beverages and snacks continue to hit the market every year.”
Despite the Health Benefits… In large part, said Mr. Parle of Kerry, the soy industry reaped the benefits of governNutraceuticals World • 41
Soy
“Soy prices are at an all-time high. This makes less expensive heart health products like whole grains more attractive.” ment-funded research on soy during the past several years. But soy isn’t the only health ingredient backed by science these days. “A decade ago, if you wanted to pursue health benefits, soy was your only choice. But now there are many more choices,” he said. Further, as the health food industry evolved, more companies realized that consumers were not prepared to wait to see if they could prevent heart disease or cancer, Mr. Parle explained. “As a result, there has been a move away from products that offer benefits years down the road toward those that offer more immediate benefits.” While soy spent many years enjoying a solid healthy halo, recent years have not been as kind. Soy and breast cancer and soy and infant health are two areas that have been impacted recently. Setting the record straight on the former, the Soyfoods Association of North America said, “Conflicting results from studies on soy’s connection to breast cancer often leave consumers confused. As more research is published, there is stronger support for the role of soy foods in reducing the risk of breast cancer—especially when soy is consumed during childhood and adolescence. More and more research also suggests that women who are at risk for developing breast cancer or who are breast cancer survivors can safely consume moderate amounts of soy foods—anywhere from a few servings a week to three servings a day.” Despite its health benefits, high prices for soy motivated consumers to exchange soy foods for products based on less expensive ingredients such as whole grains, including wheat, barley and oats. Based on Mintel’s consumer survey, 22% of non-soy users say they do not buy soy because it is too expensive.“Soy prices are at an all-time high. This makes less expensive heart health products like whole grains more attractive,” Mintel explained. “This competitive set of products had a particularly negative impact on segments like cookies and snack bars, chips and pretzels, which each lost sales during 2008-10.” 42 • Nutraceuticals World
Meanwhile, instead of focusing on specific benefits like reducing the risk of heart disease, many companies are stepping back to concentrate on soy’s generic attributes. In keeping with soy’s reputation as a health food, purity claims like “natural,” “organic” or “no additives and preservatives” rank in the top 10 claims soy food and beverages made during 2006-10, as monitored by Mintel’s Global New Products Database (GNPD). Such claims, the market researcher said, help brands stand out in meeting consumers’ desires for foods that promote wellness. For others, promoting the health benefits of soy sometimes comes down to regulations.“Eating soy for its health benefits is a geographic issue. Companies are always trying to look for health claims but the reality is there are a lot of differences in regulations—especially in Europe, which has only approved one claim related to soy and cholesterol reduction,” said Solbar’s Mr. Krause. “Regardless, people want to become healthier as they eat and soy is playing a nice role as a healthier alternative to unhealthy options.” To address some of today’s broader issues, Mr. Parle said Kerry is adjusting its focus on consumer groups.“One part of the soy business is following a cost-yield path, sometimes using GMOs to make more affordable, more nutritious products,”he said. “The other part of the market is focusing more on affluent consumers, who are moving away from GMOs and buying organic as a safer alternative.” As for those in the middle, Mr. Parle said, this has become a dead space. “This segment of the market is not doing well.” “We’re interested in connecting with more educated, more affluent consumers and aggressively developing higher-end soy ingredients to appease their concerns,” Mr. Parle added.“These consumers are concerned less with price, and more with safety, environmental footprint and health. We are trying to do what we can on the soy side to attract these consumers.” For example, he said Kerry has develwww.nutraceuticalsworld.com
oped a 99.95% GMO-free soy product.“We hope to be at 99.99% very soon, meaning there will be virtually no GMOs in the material. Some folks are weary of GMOs, so this would address those issues.” At the same time, the company is making the harvesting of its soybeans more environmentally friendly. “The whole idea is to completely avoid hexane in the production of soy,”Mr. Parle said.“We have developed a range of isolates produced without the use of hexane. Functionally and nutritionally they are almost identical to our other isolates.”
Soy’s Future Soyatech’s Mr. Jordan predicted the soyfoods industry would continue to grow at a relatively slow rate (1-2% per year), which he said is typical of a mature food category. “The lines between soyfoods and other healthful, vegetarian food options will become blurred as consumers will care more about convenient, delicious nutrition than about the source of protein,” he explained. “The impact of negative health stories will be largely blunted by the weight of scientific evidence finding soy to be a healthful component to a balanced diet. Taste concerns will be mitigated—though not erased—by further breakthroughs in processing technology.” SunOpta’s Mr. Golbitz offered a similar perspective.“We believe the soy market will see slow, steady growth and be strong a decade from now. With rising food prices, soy will be an increasingly significant part of how we feed mankind,” he commented. “The developing world needs more protein, and with the high cost of food many will need to turn to vegetable protein.” In the developed world, Mr. Golbitz believes soy will fare differently than in the developing world and be based on other factors, such as trends and demographics. “Soy will have its cycles, but we do think it will see growth in the future, especially if there are issues with dairy or meat safety,” NW he concluded. June 2011
=76
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(R)evolution
Flavors Colors
in
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Balancing flavor with healthfulness while keeping costs low may prove to be the magic formula. By Sean Moloughney Associate Editor
It’s hard to put a price tag on taste. Not surprisingly, it remains the top consideration (87%) for consumers when deciding which foods and beverages to purchase, according to the International Food Information Council (IFIC) Foundation “2011 Food & Health Survey.” Other motivators include price (79%)—which, interestingly, increased 6% from 2010 and 15% since 2006— along with healthfulness (66%), convenience (58%) and sustainability (52%). But, clearly, taste remains an overriding factor that will make or break the success of products in the marketplace. “Few consumers are willing to trade taste for functionality, and successful brands in this space must deliver both,” said Suzanne Niekrasz, director of marketing communications, Robertet Flavors Inc., Piscataway, NJ. “This fact is driving flavor innovation in such critical areas as 44 • Nutraceuticals World
masking agents and bitterness blockers, as well as sweet and salt flavor enhancers.” Additionally, a growing number of consumers who are increasingly aware of—and are looking to avoid—artificial colors, preservatives and ingredients they cannot pronounce or recognize, have been driving a shift in how companies develop flavor profiles for their products. “One illustration of this is the conversation consumers are having about ‘natural’ sweeteners,” Ms. Niekrasz noted.“Is HFCS (high-fructose corn syrup) natural? Although the FDA has declared that it is, there are consumers who do not accept this, which is driving increasing use of ‘more natural’ sweeteners like cane sugar in product formulations. The consumer is king and their perceptions and desires, rather than hard science, will continue to drive ingredient selection.” New product activity in the global soft www.nutraceuticalsworld.com
drinks market reflects rising consumer interest in health and naturalness, according to Netherlands-based Innova Market Insights, which has indicated that the most popular health-related claims in 2010 revolved around naturalness and freedom from artificial additives and preservatives. More than 20% of launches recorded by Innova Market Insights were marketed as free from additives and preservatives, while more than 10% were marketed as natural. Combining the two categories resulted in nearly one-third of total soft drinks launches using either one or both claims.
This article in a nutshell: • Challenges • Tasteful trends • Colorful debate
June 2011
Flavors & Colors
Thanks to a push toward natural products, alternative sweeteners like stevia and monk fruit (lou han gou) are starting to gain mainstream acceptance. For example, a study by U.K.-based food and drink consultancy Zenith International estimated that worldwide sales of stevia reached 3500 metric tons in 2010, a 27% increase from 2009, taking its overall market value to $285 million. Zenith predicted the global market for stevia would reach 11,000 metric tons by 2014, equivalent to $825 million by value.
Challenges However, alternative sweeteners, which often taste bitter, have challenged formulators to rethink traditional approaches to product development. Offering healthy products that also appeal to consumer tastes involves overcoming factors such as interactions between ingredients, shelf-life issues and different processing conditions, Robertet’s Ms. Niekrasz noted. No single flavor ingredient can provide a solution to all these issues. “Instead, flavorists and applications technologists are becoming adept at
pulling together flavor compounds that will work in very specific product applications and ingredient matrixes,” she said. “As a result, flavor houses are partnering with brand developers much earlier in the formulation process than ever before. Customized flavor development is of paramount importance, since off-theshelf library flavors will rarely—if ever— match the effectiveness of such optimized flavor solutions.” Color, aroma and texture are all very important considerations when developing an overall concept profile, said Jessica Jones-Dille, senior manager, Industry Trends & Market Research, WILD Flavors, Inc., Erlanger, KY. “The mouthfeel of the product (texture) can change significantly based on the ingredients used and ingredients must work synergistically to create a balanced overall product. Sensory testing is important to ensure that the product is not only marketable, but meets a consumer’s expectation for a healthy product.” Brandon Olson, director of research and development, Premium Ingredients International, Carol Stream, IL, agreed, saying there are several sensory factors to con-
sider when developing a flavor profile. “The two more obvious elements would be taste and odor, but some underrated characteristics would be mouthfeel, apparent sweetness and actual color of the flavor,” he said. “A flavor used in high concentrations can actually add mouthful, making a beverage appear to contain sugar or fat. Low calorie products can benefit from adding certain aroma chemicals that give the appearance of being sweet without actually adding costly sweeteners.” Authenticity also plays an important role in meeting expectations of taste. “When our customers receive a brown vanilla flavor or a yellow butter flavor, there can be an almost subliminal confidence associated with using it. The more organoleptic elements we can correctly peg when making a flavor lead to a more authentic profile in the minds of our customers.” As more consumers look for natural health products that taste good, cost will continue to present a challenge to manufacturers, according to Mr. Olson.“Natural and organic flavors are challenging when starting raw materials are scarce or very expensive. These materials are often de-
In the next issue of Nutraceuticals World Nutraceutical Beverages | Functional Food Formulation Annual Herbs & Botanicals Update
46 • Nutraceuticals World
www.nutraceuticalsworld.com
June 2011
Flavors & Colors
pendent on variable weather conditions and political environments, which can cause great fluctuations in price. We overcome these obstacles by selecting the same or similar essential oils from other regions and modify their profiles accordingly. Of course, the advantage of a natural or organic flavor is a very clean label and true-to-the-fruit profiles.”
Tasteful Trends Consumers continue to look for products with exotic, superfruit flavors, according to Agneta Weisz, vice president of flavors and technology, Comax Flavors, Melville, NY. “Not only are these fruits more readily available, they are also piquing the interest of consumers who are looking for new and adventurous flavors. Consumers are also becoming increasingly aware of the health attributes and antioxidant benefits from superfruits. They want simple and healthy products—good for you types of food and beverages—yet they
June 2011
also need to taste good.” She noted new flavors that combine novelty with intrigue include Manila Mango, Young Coconut and Finger Lime. “These fruits add a dash of adventure, yet are familiar to us.You will typically see these types of flavors in beverage applications.” According to WILD Favors’ Ms. JonesDille, exotic fruits continue to be important for new flavor creation because they offer uniqueness and have special characteristics in the eyes of the consumer. “It is still important in many cases to blend an exotic fruit profile with a more familiar product. However, we have seen a bit of a shift from pure fruit blends to exotic fruit ‘punches,’ (e.g., Carambola Punch) or to blending exotic fruits with herbs or spices to create a familiar profile.” In addition, varietal flavors like Anjou Pear and Macintosh Apple will grow in popularity, offering differentiation in a crowded marketplace, she predicted.“Pairing a unique taste with a more familiar taste to create a new flavor blend contin-
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ues to gain popularity for food and beverage applications.” Ms. Jones-Dille also noted a trend toward“relating the provenance of the flavor to the health benefit or origin of the featured health ingredient(s).” For example, products that contain ingredients from Traditional Chinese Medicine would also feature flavors specific to China, such as Ginger Plum. Ms. Weisz acknowledged demand for many different types of ethnic foods that span several continents. “However, while consumers want more diversity with their culinary choices, they still desire the homespun warming flavors that they grew up with, such as Gingerbread and French toast. We also continue to see a demand for decadent flavors like mint chocolate chip and dulce de leche. These flavors are becoming increasingly popular in nondessert type products such as chewing gum and yogurts.” But striking that balance between taste and healthfulness can prove difficult. Ms.
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Flavors & Colors
Weisz said flavors for nutraceutical products should align with the ingredients and match consumer expectations for the type of product they are purchasing. “Flavor, taste and appearance of any food or beverage have to work in concert,”she offered. “For instance, a grapefruit flavor may work well with a sour and bitter beverage. However, this may not be suitable if the ingredients in the beverage make it brown or gritty. In this case, one can use masking flavors to mitigate some of the undesired taste characteristics or use some other flavors that are congruent with the appearance of the beverage. Perhaps a raspberry chocolate beverage would be more acceptable for a brown beverage. If the beverage is gritty, changing the texture to a smoothie with some gums would make this beverage more acceptable.”
Colorful Debate As consumers indicate concern about the origins of the products they buy, WILD Flavors’ Ms. Jones-Dille said the use of colors from natural sources would continue to replace highly controversial artificial dyes in many product applications. Continuing a long-standing debate over a potential link between artificial food dyes and hyperactivity in children, FDA convened an expert panel of scientists in March to evaluate the evidence. Synthetic food dyes like Yellow 5 and Red 40 have been a hot topic since the 1970s, when Dr. Ben Feingold, a San Francisco allergist, reported that his patients’ behavior improved when artificial dyes were eliminated from their diet. A 2007 study from researchers at Southampton University in the U.K. also indicated a link between hyperactivity in children and the food colors. Jeff Greaves, president, Food Ingredient Solutions (FIS), Teterboro, NJ, noted the EU has erred on the side of caution, requiring foods and drinks that contain any of six artificial colors to bear a health-warning label. However, the FDA panel concluded that existing research doesn’t warrant a warning label on products that contain artificial dyes. “The one study which linked artificial colors to hyperactivity in children was likely not enough to reason a scien48 • Nutraceuticals World
tific consensus on the danger of (these) dyes,” said Mr. Greaves. “The only way to be certain is with additional, larger-scale, double-blind studies. On the supply side, it is probably for the best, as the demand from the change in the EU regulation has put a lot of pressure on the raw material supply chain.” Despite the FDA panel decision, debate still isn’t settled, according to Jeff Wuagneux, president and CEO, RFI Ingredients, Blauvelt, NY.“While the agency’s food advisory committee voted against having warning labels, it was only narrowly defeated (8-6) and the committee overwhelmingly voted for more research on the subject (13-1). More research is likely to get more media attention and consumers will only become more aware of the potential link.” Mr. Wuagneux stressed that the panel did not conclude artificial colors are safe. Instead, experts simply agreed there is not enough evidence to conclude food colorings have an effect on hyperactivity. As research continues to explore potential risks from artificial dyes, there will still be a place for them alongside natural products, said Mr. Wuagneux. “Cheaper, more processed foods will likely continue to use artificial colors. But the biggest growth in the market is in food products with fewer ingredients, especially fewer artificial ingredients.” The most popular sources of natural colors continue to evolve over time, according to Mr. Wuagneux. “Twenty years ago, the science of natural colors was still in its infancy and many of the colors that were popular then, such as grape skin extract and elderberry juice concentrate, have been overshadowed by other, more stable anthocyanin-based fruits and vegetables. Examples of such colors include purple cabbage, red radish and purple sweet potato. These colors contain more stable anthocyanins, providing longer shelf lives than the original anthocyanin-based natural colors.” Formulating with natural colors presents major challenges, most notably in terms of stability.“Even though there are more stable colors on the market than there were 10 years ago, they are still not as stable as synthetic colors,” Mr. Wuagneux noted. www.nutraceuticalsworld.com
“Another challenge is getting the exact shade from these natural colors, although that is easier than in the past because of the addition of new sources (such as red radish and purple sweet potato) and the ability of blending colors (which RFI does regularly) to find perfect shade.” Mr. Greaves said every situation presents a different set of issues to address. “Some natural colors are indicators (i.e., change color with pH). Some of them have poorer stability than synthetics, although some others are actually better. Some are unstable in certain acids, though the same is true for synthetics. Some are sensitive to metal ions. We really address all of these issues by working closely with customers to find the best option in their matrix, depending on the given solubility, pH, other ingredients, etc. It is often a very customized process.” Price has also posed an obstacle to the growth of natural colors, as artificial dyes are cheaper. However, while price plays an important part in consumer purchasing habits, many demographics have demonstrated a willingness to pay a premium for natural products, according to Mr. Wuagneux. “The major advantage of natural colors is still the ‘clean label,’” he said. “But a more natural hue is also becoming an advantage. While Baby Boomers and Generation X grew up with the vivid and bright shades of artificial colors, a large majority of them choose not to feed these to their children any longer and avoid foods that even look artificial.” Offering an example of pistachios, which had traditionally been dyed red, Mr. Wuagneux predicted more products would inevitably make the switch to natural colorings. “This was an ingrained consumer expectation—many of us didn’t even know they were dyed. But today it’s hard to find red pistachios. Somewhere along the way, they removed the artificial dye and consumers accepted the change, and embraced it. Think of all the natural candies that imitate M&Ms but use natural colors, or naturally colored energy drinks that compete with Gatorades. Ten years ago such products didn’t exist, but they will most likely be more popular and more NW common in the next 10 years.” June 2011
A Bright Outlook for
Oral
Care
By Sean Moloughney Associate Editor
As research develops, more companies will be sinking their teeth into fresh opportunities. As consumer awareness of periodontal diseases heightens, and the desire for brighter, whiter teeth begins well before the Boomer years, the market for oral care products continues to develop into an attractive category. A 2010 report from Mintel International estimated the U.S. oral care market at about $3.4 billion. However, the recession kept sales growth and new product introductions in check. Mintel noted that since 2007 the category has remained essentially flat, as many oral care consumers have trimmed back on expenditures. In addition, private label market share has risen in recent years. Toothpaste represents 38% of total sales (about $1.3 billion), nearly twice as much as the next largest segment, according to Mintel.“With nearly universal penetration, upward momentum has proven elusive,” the report added. 50 • Nutraceuticals World
However, U.S. sales of toothpaste and bleaching/whitening products reached nearly $1.6 billion for the 52 weeks ending April 17, 2011, representing more than 4% growth from the previous year, according to SymphonyIRI Group, a Chicago, ILbased market research firm. Sales data came from supermarkets, drugstores and mass-market retailers, excluding Wal-Mart, Club Stores and Gas/C-Stores. U.S. consumers spend more than $100 billion on dental services each year. Mintel indicated that with recession-inspired economizing, “oral care segments that reduce consumers’ dependence on the dentist’s office have fared well. Floss/accessories/tools and whitening products gained in 2010.” Specifically, according to SymphonyIRI Group, sales of bleaching/whitening products grew more than 7% in the past year. Meanwhile, U.S. sales of toothbrush/denwww.nutraceuticalsworld.com
tal accessories represent nearly $1.4 billion, growing almost 4% in the past year. “More than a product segment, whitening has become a pervasive theme that runs through most aspects of the oral care category,” Mintel’s report said. “More than six in 10 adults claim to have used a whitening product or service, with toothpaste the most commonly cited type. Consistent with other cosmetically focused product categories, whitening products of all kinds skew strongly to women and younger adults.”
This article in a nutshell: • The big picture • Probiotics • Natural solutions • Sweet tooth
June 2011
Oral Care
The Big Picture Product innovation in the oral care market has focused mainly on whitening teeth and addressing indications like gum sensitivity, according to Mitch Skop, senior director, New Product Development, Pharmachem Laboratories, Kearny, NJ. “Higher awareness of gingivitis, periodontal disease and resulting loss of teeth due to unaddressed gum disease have driven many more consumers to use mouthwashes and toothpastes that promise to keep periodontal disease at bay. However, dentists and oral hygienists know that is not enough. Regular deep cleanings and certain dietary supplements can promote restoration of gum health.” He noted that naturally derived ingredients have only recently come on the scene to address oral care issues, but Baby Boomers are currently seeking age-appropriate products, including dental adhesives and rinses. “Vanity still tends to rule,” he added, noting the popularity of whitening products, particularly among younger demographics. “Simply put, as more people get their twice yearly cleanings and are finding out they have gingival pockets that signify either gingivitis or periodontal disease, the more serious motivation to preserve their teeth sets in.” Dean Mosca, president, Proprietary Nutritionals, Inc. (PNI), Kearny, NJ, said that, according to Colgate.com, more than 75% of adults 35 and older have some form of gum disease.“This is alarming because more recent research has shown a correlation between gum disease and heart disease, and that there are shared risk factors.” As with many other product categories, more consumers today are looking for natural ingredients in their personal care products, according to Shaheen Majeed, marketing director, Sabinsa Corporation, East Windsor, NJ. “Although expensive natural actives were originally the prerogative of higher end brands, the emergence of a mass market has brought these ingredients to a larger consumer pool. Increasing demand for such ingredients in the face of environmental and sustainability issues, and the need for ‘green’ and organic HBA (health 52 • Nutraceuticals World
and beauty aid) products are key factors in new product development.”
Probiotics Clinical research has led to the growth of probiotics in a multitude of health categories. While science in the area of oral care remains in its infancy, researchers have acknowledged significant potential. An article in the March issue of the Journal of Clinical Periodontology, designed to explore whether the use of probiotics could influence periodontal microbiota and health, indicated a need for further evaluation. Researchers concluded that current data “indicate an effect of probiotics on the oral microbiota and a more limited effect on clinical periodontal outcome measures. However, there is an urgent need for properly conducted clinical trials where probiotics are used as adjuncts to standard periodontal care, similar to antibiotics, using probiotic strains with, at least at an in vitro level, proven periodontal probiotic effects.” Similarly, a review published in the July 2010 issue of the European Journal of Dentistry said “both research to unravel the mechanisms of possible probiotic action and long-term clinical trials are needed if probiotics are to provide a new scientifically proven means of preventing or treating oral diseases. Several health-promoting effects of probiotic bacteria are well documented, and there is no reason to restrict the use of probiotic products because their effects on oral health are not yet well understood; however, their recommendation for dental health purposes is not yet justified.” Dr. S.K. Dash, president and founder of UAS Laboratories, Eden Prairie, MN, said Streptococcus mutans is the most destructive bacterial strain in the mouth, as it attaches easily to teeth and produces large amounts of acid. “During the process of bacterial digestion of the sugars, lactic acid is produced. Lactic acid creates an acid environment around the teeth, which is able to destroy the enamel of our teeth. “Studies using orally-administered probiotics have found that certain strains can inhibit the growth of S. mutans,” he continued. “A study done on children during their early childhood reported a significant reduction in caries after 7 months of daily www.nutraceuticalsworld.com
consumption of probiotic milk,” he said. “The conclusion was that probiotics seem to be a natural way to maintain dental health, and that daily intake of probiotics in early childhood may result in fewer dental caries.” Early research indicated that Lactobacillus acidophilus DDS-1, from UAS Laboratories, was effective in treating gingivostomatitis, an acute inflammation of the mouth and gums. Dr. Dash noted L. rhamnosus also proved beneficial in the oral cavity. Research suggests the mouth, much like the digestive tract, depends on a proper balance of natural probiotic organisms to remain healthy and resist disease and decay, said Tim Gamble, senior vice president, Sales and Marketing, Nutraceutix, Redmond, WA. “In the mouth, this means the control or reduction of undesirable halitosis (bad breath), tooth decay, possibly gum disease and even tooth discoloration. By supporting the population of healthful bacteria in the mouth, throat and even sinuses, indications are that populations of pathogenic bacteria can be completely excluded and/or kept at normal levels.” Oral health products involving the application of probiotics were almost unheard of five years ago, Mr. Gamble added. However, interest has risen dramatically. “We are currently supplying and manufacturing a variety of products focused on oral health, including bulk powders (probiotic strains) as ingredients, as well as producing finished products in chewable form, from mints to berry-flavored tablets, and even pet products.” One of the most successful probiotics in the oral care market to date, BLIS K12 (Streptococcus salivarius), can now be found in chewable tablets, fast-melt tablets, lozenges, chewing gum and stickpack powders. The probiotic produces two potent anti-microbial proteins, which can act against bacteria implicated in sore throats, halitosis and diseases of the oral cavity, according to New Zealand-based BLIS Technologies. Life Extension Foundation offers Advanced Oral Hygiene, a quick-dissolving lozenge that contains a combination of BLIS K12 and Ganeden BC30 (Bacillus coagulans). Mike Bush, vice president of business development, Ganeden Biotech, June 2011
Oral Care
Inc., Cleveland, OH, said the oral care market continues to gain momentum due to strain-specific research. “Consumers are becoming aware of the fact that specific probiotics have specific utility. The best way to market products is by instilling confidence in your consumer that not only is this a good, safe product, but it’s also effective.” Other probiotic products are gaining traction in the oral care market thanks to sound science. For example, ProBiora3, from Oragenics, Tampa, FL, is a proprietary blend of three beneficial bacteria naturally present in healthy mouths, including Streptococcus oralis KJ3, Streptococcus uberis KJ2 and Streptococcus rattus JH145. The blend promotes fresher breath, whiter teeth and supports gum and tooth health, according to the company.
Natural Solutions Pharmachem’s Mr. Skop said studies dating back to the 1970s demonstrated
that CoQ10 has a positive impact on gingival tissue and reduced pocket depth. “More studies seem to confirm this action, and some progressive dentists recommend patients supplement with it. Since then, as ingredient sourcing, processing and research have improved dramatically, other ingredients have been shown to incur positive impact on dental health.” For example, green tea’s actives have been shown in trials and epidemiological research to promote gum health and reduce halitosis, Mr. Skop noted. Research published in a 2010 issue of Preventive Medicine indicated an association between green tea consumption and decreased odds of tooth loss. Another study published in the Journal of Periodontology in 2009 investigated the epidemiologic relationship between the intake of green tea and periodontal disease. A total of 940 Japanese men aged 49 to 59 were given health examinations with probing depth, clinical attachment loss and bleeding upon probing used as periodon-
tal parameters. The intake of green tea was defined as the number of cups per day in a self-administered questionnaire. Results showed a modest, inverse association between the intake of green tea and periodontal disease. Alongside green tea’s antioxidant properties, cranberries contain A-type proanthocyanidins (PACs), the phytochemical responsible for cranberry’s anti-adhesion properties, noted Dan Souza, marketing director for Decas Botanical Synergies, Carver, MA. “In fact, the same anti-adhesion mechanism of action that is responsible for cranberry’s support for urinary tract health also helps to support oral health. Cranberry PACs inhibit bacteria from adhering to teeth and forming plaque.” In 2010, Burt’s Bees launched a complete line of toothpaste that contains Decas Botanicals’ PACran cranberry ingredient, Mr. Souza added. Sea buckthorn berry has also gained attention recently for its ability to promote oral health. Dr. Gerald Curatola, a guest
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Nutraceuticals World • 53
Oral Care
on The Dr. Oz Show, recently revealed sea buckthorn as his “secret weapon” for oral health. The berry and seed oils found in sea buckthorn combat gum and dental disease through high omega content, antioxidant properties and nutritional content. These properties support the immune system and offer anti-inflammatory effects needed to improve and maintain gum and dental health. According to Don Stanek, director of sales for Linnea Inc., Easton, PA, other oral care nutraceuticals include the unsaponifiable fraction of Zea Mays, an herb in the Gramineae family of plants that is thought to reduce the mobility of the teeth, mitigate gum swelling and promote repairing of the alveolar bone by stimulating osteocytes. Zea Mays contains proteins, starch, fat, calcium, potassium, iron, vitamins B1, B2, B6, niacin, pantothenic acid, biotin, carotene, cellulose and lysine. Interest in oral health often relates to anti-microbial and anti-inflammatory activity, as well as decolorizing stains, ac-
cording to Sabinsa’s Mr. Majeed.“So for us, the most popular oral care products include Berberine HCL, coleus oil, Policosanol CG, Sapindin and Venocin.” Berberine, sourced from Berberis aristata roots, shows significant anti-microbial activity when evaluated against the oral pathogens Streptococcus mutans and Fusobacterium nucleatum, Mr. Majeed noted. Sapindin (Sapindus trifoliatus), from Soapnut Tree, may have potential application as a natural cleansing agent and for decolorizing stained teeth. Venocin, from Horse chestnut tree, supports gum integrity and pain relief, as well as antioxidant activity and circulation. PNI’s Mr. Mosca said Celadrin, a blend of cetylated fatty acids, (and its vegetarian version, Vege-Celadrin)—while known for its joint health benefits—has been found to support the inhibition of certain pro-inflammatory cytokines in cases of gingivitis. Results from an in vitro test of monocytemediated inflammatory response showed significant inhibitory actions on various
pro-inflammatory cytokines, indicating a potential role in different stages of inflammation, he added.
Sweet Tooth At a time when more consumers are looking to cut back on sugar, alternative sweeteners like stevia, monk fruit (luo han guo) and polyols (sugar alcohols) represent an important category of ingredients for the oral care market. Christos Zacharis, product service group manager, Sweeteners Division, at Danisco, said xylitol in particular offers numerous health benefits. “Xylitol has a vast amount of scientific references regarding its effect, not only on dental caries, but also on several factors leading to the disease, such as plaque and demineralization (the taking away of minerals from tooth surfaces).” In fact, the European Food Safety Authority (EFSA) recently approved a“general function”health claim for the role of a range
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June 2011
Oral Care
of sugar replacers like xylitol and sorbitol in maintaining tooth mineralization. Danisco offers several solutions that improve and maintain good oral health, according to Mr. Zacharis. “For example, Xivia—our sustainably produced xylitol— has been clinically proven to reduce plaque and dental caries and help with the remineralization of caries lesions.” Xivia can be used to replace sugar in confectionery applications and also as a supplement in toothpaste, mouthwash and teething gels, where it increases the effectiveness of fluoride, he added.“Unlike other polyols, the product has a cariostatic effect, actively preventing more caries from forming.” Chewing gum is the main form of delivery for ingredients such as xylitol, followed by chewable tablets.“Due to its high solubility, xylitol may very well be used in toothpastes as well as mouth rinse solutions or oral health sprays,” he said. “Having xylitol in a toothpaste helps raise the product’s profile.” In the U.S., 24% of children aged 2-4 years already suffer from dental caries, Mr. Zacharis added. “As diets in developing countries evolve to include more processed foods and extrinsic sugars, the incidence of plaque formation and caries can be expected to increase rapidly across the globe.” In terms of product formats, gum simply makes sense in the oral care arena, and more companies have started adding nutrients to their products. Maureen Jones, manager of Wrigley Oral Healthcare Programs at Wm. Wrigley Jr. Company, said that chewing sugar-free gum, even without the addition of health ingredients, “produces stimulated saliva, which in turn helps fight cavities, helps neutralize plaque acids, helps re-mineralize enamel to strengthen teeth and washes away food particles.” In Australia and New Zealand, Wrigley recently launched Wrigley’s Extra Professional Calcium, a calcium-fortified gum designed to deliver 10% of the recommended daily intake of calcium, offering consumers another means to obtain this mineral, which is essential to building strong bones and teeth. Patrick Stano, vice president, Sales and Marketing, North America, with Dr. Paul June 2011
Lohmann Inc., Islandia, NY, said his company has received more interest in calcium salts for re-calcification as well as other minerals like zinc, which may help prevent tartar buildup by preventing plaque from hardening, or calcifying. “We have had a number of requests for zinc compounds, such as zinc citrate and zinc gluconate, for their anti-microbial
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properties, along with magnesium and calcium peroxide for whitening, and calcium glycerophosphate and sodium pyrophosphate for tartar control,” he said. While traditional product formats for oral care include mouth rinses, toothpaste and whitening gels, Mr. Stano said more innovative applications like gum and lozenges NW are quickly coming on the scene.
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Nutraceuticals Research
Nutraceutical: Calcium Indication: Cardiovascular events Source: BMJ April 19, 2011;342:d2040. doi: 10.1136/bmj.d2040. Research: Researchers set out to investigate the effects of personal calcium supplement use on cardiovascular risk in the Women’s Health Initiative Calcium/Vitamin D Supplementation Study (WHI CaD Study), using the WHI dataset, and to update the recent meta-analysis of calcium supplements and cardiovascular risk. The purpose was the reanalysis of the WHI CaD dataset and incorporation in the meta-analysis with eight other studies. The data source in the WHI CaD Study included a 7-year, randomized, placebocontrolled trial of calcium and vitamin D (1 gram calcium and 400 IU vitamin D daily) in 36,282 community dwelling postmenopausal women. Main outcome measures included incidence of four cardiovascular events and their combinations (myocardial infarction, coronary revascularization, death from coronary heart disease, and stroke) assessed with patient-level data and trial-level data. Results: In the WHI CaD Study there was an interaction between personal use of calcium supplements and allocated calcium and vitamin D for cardiovascular events. In meta-analyses of three placebo-controlled trials, calcium and vitamin D increased the risk of myocardial infarction, stroke and the composite of
“Calcium or calcium and vitamin D increased the risk of myocardial infarction and the composite of myocardial infarction or stroke.”
myocardial infarction or stroke. In metaanalyses of placebo-controlled trials of calcium or calcium and vitamin D, complete trial-level data were available for 28,072 participants from eight trials of calcium supplements and the WHI CaD participants not taking personal calcium supplements. In total, 1384 individuals had an incident myocardial infarction or stroke. Calcium or calcium and vitamin D increased the risk of myocardial infarction and the composite of myocardial infarction or stroke. These findings led researchers to conclude that supplements with or without vitamin D modestly increase the risk of cardiovascular events, especially myocardial infarction, a finding obscured in the WHI CaD Study by the widespread use of personal calcium supplements. As a result, they believe a reassessment of the role of calcium supplements in osteoporosis management is warranted.
placebo, 500 mg (low dose) or 1000 mg (high dose) of whole cranberry powder daily for 90 days. Results: At the end of the study, no significant changes in the presence of E. coli were found in the placebo group. However, a significant reduction in the presence of E. coli was found in both the lowand high-dose treatment groups. The subjects also reported symptomatic relief in both treatment groups, while no reduction in symptoms was noted in the placebo group. Overall, it was found that a dose of 500 mg of whole cranberry powder per day reduced the recurrence of UTIs by 36%. A dose of 1000 mg per day reduced the recurrence by 65%. These findings, researchers believe, suggest that whole cranberry powder should be considered a safe and effective adjunct treatment along with antibiotics to reduce the recurrence of UTIs in women.
Nutraceutical: Benecol (plant stanol ester) Indication: Cholesterol (in statin-treated diabetics) Source: Atherosclerosis, 2011;doi:10.1016/ j.atherosclerosis.2011.03.041. Research: This study, carried out at the University of Eastern Finland in Finland, recruited 24 participants with type 1 diabetes who were on stable cholesterollowering statin medication. The mean baseline LDL-cholesterol concentration was 2 mmol/l. The subjects consumed either plant stanol estercontaining vegetable —Nutraceuticals Research is brought to you in part by Natural Standard. oil-based spread (intervention group) or a corThe Natural Standard© database is an evidence-based decision support tool that is designed to help users navigate research on the safety and efficacy of herbs, supplements, responding control vitamins, minerals, diet and exercise and nutrition products. It also assists in: spread without plant stanol ester (control Structure/Function Claims • Regulatory Affairs & Product Registration Research & Development • Employee & Consumer Education group) for 4 weeks. The intake of plant stanols in www.naturalstandard.com the intervention group To have your products listed in the brand name database, subscribe to the full professional database, or ask content was 3 grams per day. The licensing/custom report questions: contact 617.591.3341 or send your inquiries to [email protected]. subjects were advised to
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Nutraceutical: Cranberry Indication: Urinary tract infections (UTIs) Source: Current Bioactive Compounds, March 2011;7(1):39-46. Research: A randomized, double-blind, controlled clinical trial sought to evaluate the efficacy of whole cranberry powder in preventing urinary tract infections (UTIs). The study included 60 women between the ages of 18 and 40 years who were randomly selected to receive either
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June 2011
Nutraceuticals Research
make no changes to their usual diet and lifestyle and to remain on their prescribed statin treatment. Results: The results showed that plant stanol ester effectively lowered cholesterol. Total and “bad” LDL-cholesterol were reduced by 8% and 15%, respectively, in the intervention group compared with the control group, while triglyceride concentrations and “good” HDL-cholesterol remained unchanged. Nutraceutical: Omega 3 DHA Indication: Postpartum depression Source: Experimental Biology Conference, April 2011. Research: Investigators conducted a randomized, double-blind, placebo-controlled dietary intervention trial in which 52 pregnant women took either a placebo (corn oil) or a fish oil capsule containing 300 mg of DHA 5 days each week from 24-40 weeks of pregnancy. This is the amount a woman would consume if she ate about a half serving of salmon. It is noteworthy that dietary DHA intake during pregnancy has been estimated to be 50-70 mg of DHA daily—a mere fraction of the 200 mg daily that is considered optimal during pregnancy by most experts. Results: Although the study did not have enough women to investigate if fish oil consumption resulted in a lower incidence of diagnosable postpartum depression, women in the treatment group had significantly lower total Postpartum Depression Screening Scale scores, with significantly fewer symptoms common to postpartum depression. For example, compared to those in the control group, women in the fish oil group were less likely to report symptoms related to anxiety and loss of self. As a result, researchers believe DHA consumption during pregnancy—at levels that are reasonably attained from foods—has the potential to decrease symptoms of postpartum depression. Nutraceutical: Omega 3 DHA Indication: Prostate cancer Source: Am J Clin Epidemiol, April 25, 2011; [Epub ahead of print]. Research: Inflammation may be involved in prostate cancer development and proJune 2011
gression, so researchers examined the associations between inflammation-related phospholipid fatty acids and the 7-yearperiod prevalence of prostate cancer in a nested case-control analysis of participants, aged 55-84 years, in the Prostate Cancer Prevention Trial during 1994-2003. Cases (n = 1658) were frequency matched to controls (n = 1803) on age, treatment and prostate cancer family history. The clinical trial was unique in that prostate biopsy was used to confirm the presence or absence of prostate cancer in all study participants. Among the study participants, very few took fish oil supplements—the most common non-food source of omega 3 fatty acids, which are known to prevent heart disease and other inflammatory conditions. The majority got omega 3s from eating fish. Results: DHA was positively associated with high-grade disease. In fact, researchers found that men with the highest blood percentages of DHA, an inflammation-lowering omega 3 fatty acid, had two-and-a-half-times the risk of developing aggressive, high-grade prostate cancer compared to men with the lowest DHA levels. The study findings are contrary to those expected from the proand anti-inflammatory effects of these fatty acids and suggest a greater complexity of effects of these nutrients with regard to prostate cancer risk, researchers said. Nutraceutical:Vitamin E, soy and selenium Indication: Prostate cancer Source: J Clin Oncol, May 2, 2011. [Epub ahead of print]. Research: High-grade prostatic intraepithelial neoplasia (HGPIN) is a putative precursor of invasive prostate cancer (PCa) and preclinical evidence suggests vitamin E, selenium and soy protein may prevent the progression of HGPIN to PCa. This hypothesis was tested among 300 men in a randomized phase III double-blind study of daily soy (40 grams), vitamin E (800 IUs) and selenium (200 μg) consumption versus placebo. Treatment was administered daily for 3 years. Follow-up prostate biopsies occurred at 6, 12, 24 and 36 months post-randomization. Results: For all patients, the median age was 63 years. The median baseline prostate-specific antigen (PSA; n = 302) www.nutraceuticalsworld.com
was 5.41 ug/L; total testosterone (n = 291) was 13.4 nmol/L. Invasive PCa developed among 26% of patients. Gleason score distribution was similar in both groups, with 83.5% of cancers graded Gleason sum of 6. Baseline age, weight, PSA and testosterone did not predict for development of PCa. The supplement was well tolerated with flatulence reported more frequently (27% vs. 17%) among men receiving micronutrients. According to researchers, this trial does not support the hypothesis that combination vitamin E, selenium and soy prevents progression from HGPIN to PCa. Nutraceutical: Wellmune Indication: Allergy symptoms Source: Experimental Biology Conference, April 2011. Research: This study equally divided 48 healthy subjects (31 female, 17 male; 39 ± 13 years of age) into two groups. One group consumed a placebo while the other a 250 mg serving of Wellmune WGP daily for 4 weeks during last September/October in an area of southeast Ohio where local pollen counts were high. Allergy surveys, including the validated Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), were used to assess differences in allergy symptoms. Results: Individuals consuming Wellmune WGP, a natural immune health ingredient from Biothera, noted statistically significant reductions in overall allergy symptoms and severity, as well as reductions in key nasal and eye-related allergy symptoms. There was also significant improvement on the Quality of Life Index, a scientifically validated tool for measuring how participants rate their overall sense of wellness.
Log on, learn more @ nutraceuticalsworld.com Find out everything you wanted to know and more about Beta-Glucans when you visit our online “Research” section and download the Natural Standard monograph from our “Monograph Center.”
Nutraceuticals World • 57
Supply Source
Consumer Product Testing Co.: 35 Years of Excellence in Testing After more than three decades in the testing business, Consumer Product Testing Co. (CPTC), Fairfield, NJ, is renewing its clientfocused commitment in several industries, including personal care, pharmaceuticals, medical devices, specialty chemicals and dietary supplements. The latter has become a major focus for the company in recent years for several reasons. “With so much concern over the presence of contaminants in dietary supplements and other consumer products, CPTC now offers testing for low-level residues and contaminants featuring gas chromatography with
and demonstrating the safety of ingredients or products.” While these services are necessary in today’s marketplace, CPTC believes lowcost testing options should also be available. To that end, the company values cost-saving alternatives when it comes to testing, given tightening budgets not only in the U.S., but also around the world. “Although CPTC offers raw material and product testing using USP methodologies, we also offer alternative, validated methodologies at a significant savings over the USP methods,”Mr. Neumann explained.“For ex-
“Recognizing the tremendous changes the dietary supplement industry is undergoing, CPTC is determined to meet the industry’s new and evolving needs in the marketplace.” mass spectrometry detection (GC-MS) and inductively-coupled plasma (ICP),” said Bill Neumann, vice president of quality and regulatory affairs. An industry veteran who has 20 years of experience with major players, Mr. Neumann understands the complexities of dietary supplements and thus the importance of testing and research.“CPTC offers consulting services in the form of auditing, quality system improvement, development of cost-effective compliance strategies, validation and FDA remediation,” he said. “CPTC’s Clinical Division can also design client-specific clinical studies for the purpose of substantiating claims 58 • Nutraceuticals World
ample, we can test for all water-soluble vitamins in a single chromatographic set-up. We can do the same for all oil-soluble vitamins. These two procedures replace the numerous vitamin-specific assays currently in USP, resulting in shorter turnaround times and much lower testing costs for our clients.” Recognizing the tremendous changes the dietary supplement industry is undergoing, CPTC is determined to meet the industry’s new and evolving needs in the marketplace. “Our goals are to continue to provide our clients with the personal attention necessary in an ever-changing economic and regulatory environment, so that we can assist our clients in attaining their goals,” said Debbie www.nutraceuticalsworld.com
Neumann, vice president.“We do that with experience, an increased level of compliance and an understanding of the issues that our clients face every day. “As an internationally recognized laboratory, we hope to increase our presence in the emerging marketplaces around the world that would benefit from our 35+ years in the testing industry,”she added.“We are consistently updating our communication capabilities to be competitive and responsive 24 hours a day.” While CPTC remains client-focused, it also puts a lot of emphasis on serving markets abroad. “One of the reasons CPTC was founded 36 years ago was to improve the client experience through extraordinary scientific and customer service,” said Lon Weiss, CEO. “We are constantly looking at client service and how we can improve our systems. With the regulatory environment worldwide constantly changing, many clients need expertise in methods performed for overseas markets as well as domestically.” Mr. Weiss went on to say that CPTC is looking to expand its programs by partnering with its overseas and multinational clients to develop compliant testing programs. At the same time, he said,“Expanding overseas has to be done in a way that does not reduce the integrity and accuracy or harm the quality of the end product— the “Study Report.” CPTC intends on continuing to build our business in emerging marketplaces in the same client-focused, responsive, scientific manner that has made us into an internationally recognized leader in this industry.” — R.W. Consumer Product Testing Company 70 New Dutch Lane Fairfield, NJ 07004 Telephone: 973-808-7111 Fax: 973-244-7535 E-mail: [email protected] Website: www.cptclabs.com June 2011
New Products
Splenda Essentials
mg of sodium. The cereal is also fortified with several vitamins and minerals.
McNeil Nutritionals, LLC, Fort Washington, PA, has released its Splenda Essentials line of zero-calorie sweetener products, which includes Splenda Essentials with B Vitamins, Splenda Essentials with Antioxidants and the previously introduced Splenda Essentials No Calorie Sweetener, 1 gram of Fiber (in packets and granulated form). Splenda Essentials with B Vitamins contains 20% of the Daily Value (DV) for vitamins B1 (thiamine), B5 (pantothenic acid) and B6 (pyridoxine) per packet. One packet of Splenda Essentials with Antioxidants contains 20% of the DV for antioxidant vitamins C and E.
100% Natural Lipton Iced Tea PepsiCo, Purchase, NY, and U.K.-based Unilever have launched 100% Natural Lipton Iced Tea, a new line of beverages with a simple, all-natural ingredient list. Lipton Iced Tea is a product of the Pepsi Lipton Tea Partnership. 100% Natural Lipton Iced Tea is available in four flavors: Green Tea with Citrus, Iced Tea with Lemon, Iced Tea with Blueberry Pomegranate and Green Tea with Passionfruit Mango.
All-Natural Kashi Waffles Kashi Company, La Jolla, CA, has launched Kashi 7 Grain Waffles and Kashi Blueberry Waffles. Each serving of Kashi 7 Grain Waffles is an “excellent source” of fiber, with 7 grams, and contains 590 mg of ALA omega 3s. Kashi Blueberry Waffles are also an “excellent source” of fiber, with 6 grams, as well as 23 grams of whole grains and 560 mg of ALA omega 3s.
Layena Plus Omega-3 Land O’Lakes Purina Feed LLC, St. Louis, MO, has launched Purina Layena Plus Omega-3, a complete pelleted layer June 2011
Vectomega & Bio-Typed Plant Oils
feed that is formulated to enhance the omega 3 content of eggs. Made with the same natural grains as the original Layena feed, the product contains added flaxseed. Layena Plus Omega-3 is formulated to produce more than 200 mg of omega 3s per large egg and has a natural vegetarian formula with added vitamins, minerals and trace nutrients, without added antibiotics or hormones. It also contains marigold extract for rich golden yolks, key levels of calcium and manganese for strong shells with fewer cracks and an optimized level of vitamin E to support a healthy immune system.
Rice Krispies Gluten Free Kellogg Company, Battle Creek, MI, has introduced Kellogg’s Rice Krispies Gluten Free cereal alongside the original variety. The new cereal eliminates barley malt (the source of gluten in the original Rice Krispies cereal) and is made with whole grain brown rice to differentiate it from the original and for flavor. Each serving of the new gluten-free cereal contains 120 calories, less than 1 gram of sugar, 1 gram each of fat and fiber, 3 grams of protein and 190 www.nutraceuticalsworld.com
Europharma, Green Bay, WI, has introduced Vectomega, an omega dietary supplement derived from salmon. Using a patented process call “Vectorization,” the omega 3 fatty acids are naturally attached to phospholipids, enhancing absorption, according to the company. Vectomega is the result of a collaboration of the French government and the University of Nancy (France) for a research endeavor. In 2001, the French government, in conjunction with the National Interprofessional Office for Sea Products and Aquaculture, asked researchers to investigate potential uses for salmon. This governmental research project gave rise to the patented Vectorization process and Vectomega, which is distributed in the U.S. by Europharma. The company has also introduced BioTyped plant oils, which are highly concentrated and “fingerprinted” based on specific molecular makeup, species, marker compounds, purity and safety for internal medicinal use. EuroPharma offers a broad selection of Terry Naturally brand supplements that contain Bio-Typed oils, including: Sinucare, 12 Hour Energy Caps, Terrific Zzz’z Sleep Formula, Viragen, Candida Check and Wild Moroccan Oregano.
GREENSuperFood Antioxidant & Greens Powder Amazing Grass, San Francisco, CA, has launched GREENSuperFood Antioxidant & Greens Powder, which contains 15,000 ORAC (Oxygen Radical Absorbency Capacity) units per serving. The product helps the body defend against the effects of free radicals and supports healthier skin, brain function and the immune system, according to the company. Nutraceuticals World • 59
New Products
Resveratrol with Pterostilbene, which contains pTeroPure brand pterostilbene. The product contains 250 mg of resveratrol and 25 mg of pterostilbene.
CaféFit Dieting Blend
HealthyShot with Wellmune WGP Hormel Health Labs, Savannah, GA, a division of Diamond Crystal Brands, has expanded its line of HealthyShot wellness products to include several powdered beverages containing Wellmune WGP, a natural immune health ingredient. Available in Lemonade, Pomegranate-Cherry and Raspberry-Green Tea flavors, the products combine the convenience of powdered beverages and the clinically proven immune support of Wellmune WGP.
ZICO Chocolate ZICO, Hermosa Beach, CA, has introduced its ZICO Pure Coconut Water in Chocolate flavor. ZICO Chocolate features a blend of coconut water, coconut cream, cocoa and vanilla. The new flavor contains 110 calories per 14-oz. bottle, as well as 20% more potassium than ZICO’s other flavors. It is also a “good source” of iron and magnesium.
Assure for Heart & Energy Assure Food & Beverage Company, Los Angeles, CA, has expanded its line of functional beverages to include Tropical Tangerine with D-Ribose and Kiwi Strawberry Melon with Omega 3. Kiwi Strawberry Melon Assure for Heart contains 32 mg of EPA and DHA omega 3 fatty acids per serving. Tropical Tangerine Assure for Energy contains D-ribose.
Solaray Super Resveratrol with Pterostilbene Nutraceutical International Corporation, Park City, UT, has launched Solaray Super 60 • Nutraceuticals World
CaféFit has launched CaféFit Dieting Blend, a new coffee blend formulated to burn fat, boost metabolism, curb appetite and provide essential vitamins and nutrients, the company claims. The product contains Garcinia cambogia extract, derived from the rind of a small citrus fruit grown in Southeast Asia. CaféFit Dieting Blend is made with 100% Arabica coffee beans harvested in select regions of Latin America.
lant crash. The product is also formulated to suppress appetite and enhance mood.
ResLina Nutritional Earth has launched ResLina, a resveratrol dietary supplement in capsule form that contains 99% high purity Resvida trans-resveratrol, muscadine grape seed extract and organic spirulina. This patent-pending plant supplement is designed to combat cellular aging while supporting disease prevention and weight loss, according to the company.
Keratin Booster Reserveage Organics, Gainesville, FL, has launched Keratin Booster, which contains Cynatine HNS Keratin a bioactive form of keratin, along with biotin and resveratrol. Keratin is a protein found naturally in the body, which aids in protecting and repairing damaged hair, nails and skin, according to the company.
Big Shotz U.K.-based Shotz Health has launched Big Shotz multivitamin and mineral juice shot, which contains MEG-3 brand omega 3 EPA/DHA. Each 120 ml bottle of Big Shotz contains 179 mg of omega 3, as well as 11 vitamins, six minerals, prebiotics, antioxidants and ginseng. The product is available in Mango and Passionfruit flavors.
Peaceful Sleep
Energy Drinks
ZonePerfect Sweet & Salty Nutrition Bars
Bonavitas, Provo, UT, has launched a line of natural, non-alcoholic energy drinks. Sweet16 and Virgin Tequila offer thermogenic properties. Sweet16 contains capsaicin, honey, lemon, lime, quercetin, Moringa oleifera and neem. The product is designed to help burn fat, improve mood and fight free radicals, according to the company. In addition, R12 is a recovery drink that combines protein with carbohydrates.
AgroLabs, Hillside, NJ, has launched Peaceful Sleep, a 3-oz. shot supplement designed to promote nighttime relaxation, rejuvenation and renewal for a natural and healthy sleep, according to the company. The product contains chamomile, passionflower, lavender extract and aloe.
Abbott Nutrition, Abbott Park, IL, has added Sweet & Salty nutrition bars to its
Phenorex Gaspari Nutrition, Lakewood, NJ, has released Phenorex, a weight loss supplement that contains Advantra Z, a patented bitter orange extract. According to the company, Phenorex increases thermogenesis, which elevates the metabolic rate to burn fat, and provides long-lasting energy without resulting in a stimuwww.nutraceuticalsworld.com
ZonePerfect product line. Available in Cashew Pretzel and Trail Mix flavors, these bars are an“excellent source”of protein (10 grams), a“good source”of 19 vitamins and minerals and are rich in antioxidants (vitamins C and E and selenium). June 2011
Suppliers Corner
Zychrome InterHealth Nutraceuticals has launched Zychrome, a new form of chromium that has been shown in a randomized, double-blind, placebo-controlled study to significantly decrease insulin resistance and fasting insulin levels in diabetic subjects. Reductions of 30% were seen for both insulin parameters after three months of supplementation. Zychrome also significantly decreased inflammatory cytokine TNF-α levels by 21%. Reductions in this metabolic marker may help lead to normal insulin and blood sugar control. Zychrome is a unique form of chromium, niacin and L-cysteine called chromium dinicocysteinate, according to the company. For further information: www.interhealthusa.com
Cardiovascular Inflammation Ingredient Provexis plc has developed a naturally derived ingredient designed to tackle cardiovascular inflammation. The company has identified isothiocyanates contained in certain cruciferous vegetables such as broccoli, mustard seeds and watercress as having a positive effect on heart health. The ingredient currently exists as a freezedried powder, which Provexis aims to incorporate into dietary supplements, with a liquid format suitable for beverage applications also a potential solution. Provexis has developed novel intellectual property around four extracts, for which it has filed global patents. Preliminary clinical trials are now underway at the Institute of Food Research in Norwich to establish an effective dosage of the extract. The formulation will then be refined ahead of human trials planned as part of a cardiovascular inflammation study next year. For further information: www.provexis.com
Sweet Dreams for Kids Anlit Advanced Nutrition has launched June 2011
Sweet Dreams, a dietary supplement format designed for children (aged 1-14) to sleep better during the night. Each sugarfree, Vanilla-flavored yogurt bear contains 75 mg of Lactium, a milk casein hydrolysate. Anlit has developed a high stability, anhydrous matrix in addition to single-sealed units for each bear to increase the product shelf life. For further information: www.anlit4kids.com
AssureiTEA Wellbeing Kemin Health has introduced AssureiTEA Wellbeing, an all-natural, proprietary blend of green and black teas formulated to provide optimal levels of catechins and theaflavins. The ingredient provides 40% polyphenols and uses a gentle water extraction of select tea varieties to ensure beneficial antioxidant capacity. For further information: www.kemin.com
Premium DDS Probiotic Blends UAS Laboratories, Inc. has introduced Premium DDS Probiotic Blends, six condition-specific probiotic blends that contain Lactobacillus acidophilus DDS-1. Blends are available in bulk powder, bulk capsules, as branded products or private label products. DDS Probiotic Blend No. 1 contains L. acidophilus DDS-1, Bifidobacterium longum plus FOS (6 billion CFU/gram). This synergistic probiotic blend promotes digestive health and immune function. DDS Probiotic Blend No. 2 contains L. acidophilus DDS-1, B. lactis plus FOS (6 billion CFU/gram) and is specially formulated for children. DDS Probiotic Blend No. 3 contains L. acidophilus DDS-1, B. longum, B. lactis, B. bifidum plus FOS (12 billion CFU/gram). A clinical case study demonstrated the effectiveness of this probiotic blend in relieving the symptoms of irritable bowel syndrome (IBS). DDS Probiotic Blend No. 4 contains L. acidophilus DDS-1 plus FOS www.nutraceuticalsworld.com
(6 billion CFU/gram). This blend has been a subject of more than 200 university and clinical studies for various health conditions, including digestive health maintenance and boosting the immune system, according to the company. DDS Probiotic Blend No. 5 contains DDS probiotics (6 billion CFU/gram) along with a blend of cranberry fruit extract and natural Dmannose. This patent-pending blend is designed for women’s health, with a focus on urinary tract health, digestive health, immune function and maintenance of healthy yeast levels. DDS Probiotic Blend No. 6 contains L. acidophilus DDS-1, B. longum, B. lactis, B. bifidum, FOS (5 billion CFU/gram) and Parry Organic Spirulina. Research shows this blend plays a role in supporting digestive health, immune function and healthy aging. For further information: www.uaslabs.com
Baobab Fruit Powder BI Nutraceuticals has introduced baobab fruit powder. Indigenous to Africa, baobab fruit contains high levels of vitamin C, calcium, potassium, magnesium and zinc to help support the immune system, promote healthy bones and teeth and maintain cardiovascular health, including normal blood pressure levels. Baobab fruit powder can be used in a variety of applications, including: bodybuilding/fitness supplements; vitamin/mineral formulas; smoothies, fruit juices and powdered drinks; breakfast cereals and cereal bars; and ice creams, yogurts and dairy products. For further information: www.binutraceuticals.com
Purefruit Tate & Lyle has introduced Purefruit, an extract made from monk fruit, or luo han guo, that can be formulated into a variety of foods, including beverages, dairy, cereal, confectionery and bakery products. Nutraceuticals World • 61
Suppliers Corner
A fruit-based, calorie-free sweetening ingredient, natural monk fruit extract offers a way to reduce sugar and calories in foods and beverages. For further information: www.tateandlyle.com
‘Be Fit’ Extracts Martin Bauer Inc. has released Be Fit— Extracts for Body Brain in the U.S. The product concept provides new formulations and ingredients based on the performance-enhancing properties of natural tea and herbal extracts to boost both mental and physical performance. The concept focuses on three health categories: Energy, Body Vitality and Brain. Energy extracts include green maté, guarana and kola nuts. Using these ingredients to develop energy shots provides the ideal vehicle for delivering highly stimulating power in a short period of time, according to the company. Body Vitality extracts come from fruits and herbs such as baobab, acerola, dami-
ana and rhodiola, and include fibers, vitamin C, natural caffeine, polyphenols and other active compounds. In addition, independent scientific studies commissioned by Martin Bauer have demonstrated the positive functional value of ginkgo, ginseng and green tea extracts on mental performance and cognitive abilities. For further information: www.martin-bauer-group.us
Chewing Gum with Lactium Gumlink has introduced a new chewing gum concept formulated with Lactium. The product concept is intended to reduce stress-related symptoms and features Gumlink’s patented bi-layered compressed chewing gum. Lactium is derived from the protein found in cows’ milk. It has been clinically proven to reduce stress related symptoms such as tension, insomnia and high blood pressure. For further information: www.gumlink.com
Research Highlights Dairy Consumption Tied to Lower Incidence of Metabolic Syndrome The consumption of dairy products, including cheese alone, was associated with decreased incidence of metabolic syndrome and associated risk factors for cardiovascular disease, according to research findings recently published in Diabetes Care. Results also showed that consumption of dairy products other than cheese, and calcium intake, were associated with a decrease in the incidence of type 2 diabetes or impaired fasting glucose. This study supports previous epidemiological research that associated dairy intake with a lower prevalence of obesity-related chronic diseases. Metabolic syndrome is a condition characterized by the presence of at least three metabolic abnormalities, including central obesity, high blood pressure and impaired glucose and lipid metabolism, which are risk factors for cardiovascular disease. The study examined Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR), a nine-year prospective study that surveyed 3435 individuals in France using a food frequency questionnaire at baseline and after three years. The authors examined dietary intake of three categories: dairy products excluding cheese, cheese specifically and overall calcium density of the diet. The results were adjusted to exclude confounding variables, including body mass index (BMI). Another recent research study also demonstrated that the
62 • Nutraceuticals World
Ancient Grains SK Food International has added a line of identity-preserved, certified-organic and conventional, non-GMO Ancient Grains to its ingredient line. The line includes amaranth, quinoa, millet, sorghum, spelt and teff. In addition to offering the individual grains in their whole form, SK Food also supplies Ancient Grains as precooked flakes and raw flours, which can be incorporated into a variety of food applications such as cereals, tortillas, snack foods, baby food, flat breads, baking mixes and energy bars. For further information: www.skfood.com
Brown Seaweed Extract Cactus Botanics has launched a variety of grades of brown seaweed (Laminaria japonica) extract for the dietary supplement industry. Laminaria japonica contains high levels of fucoidan, a unique phytochemical that has been shown to offer various health benefits. Cactus
nutrient combination of calcium and milk fat present in dairy may play a role in reducing fat absorption and may help maintain good cholesterol while minimizing any increase in bad cholesterol. The study, published online in the February issue of the British Journal of Nutrition reinforced findings published in the 2010 Dietary Guidelines Advisory Committee report indicating that “bioactive components that alter serum lipid levels may be contained in milk fat.” For further information: www.usdairy.com Research on Beta-Glucans Published in Nature A new study published in the journal Nature features Biothera’s beta-glucans and new discoveries regarding how these immunomodulating compounds prime the innate immune system to protect the body. This research confirmed that not all beta-glucans are alike. Led by David Underhill, PhD, researchers demonstrated that beta-glucan size and molecular structure are critical to receptor binding and the resulting innate immune cell response. Dr. Underhill and his research team found that specific beta-glucan structures bind to a particular receptor (Dectin-1) while other beta-glucans structures may not. The study shows that Dectin-1 distinguishes between direct microbial contact and detection of microbes at a distance, a distinction that enables effective microbial killing responses. When bound to Biothera’s Wellmune WGP, Dectin-1 signaling primed immune cells for phagocytosis, a mechanism used to recognize and destroy pathogens.
www.nutraceuticalsworld.com
June 2011
Suppliers Corner
Botanics provides two distinctive derivatives of brown seaweed for a host of dietary supplement formulas, including brown seaweed powder extract (20:1 to 75:1, with more than 50% polysaccharides). With 50% minimum alginates, this version is suitable for cosmeceutical formulations. In addition, the company offers brown seaweed-derived fucoidan 85% (pharmaceutical- and food-grade applications), fucoidan 20% and 35%. For further information: www.cactusbotanics.com
YO-MIX Yogurt Cultures Danisco has added to its YO-MIX range of drinkable yogurt cultures with specific, tailored YO-MIX cultures that cater to local taste demands. The company has developed specific methods to select the best ingredients to fit various types of drinkable yogurt across the globe. The company can also complement its YO-MIX cultures with other Danisco value-added ingredients,
such as Grindsted pectin stabilizers, HOWARU premium probiotics or XIVIA sustainable xylitol. For further information: www.danisco.com
Lyc-O-Beta 1% CWS Pelargonium Root Extract for Colds Frutarom USA has introduced EFLA 956 Pelargonium Root Extract (PRE), which is designed to target immune health and reduce the severity and duration of the common cold and associated symptoms, including sore throat, stuffy nose, cough and mucus build-up, according to the company. Pelargonium’s triple-action profile offers functionality as an anti-microbial, an anti-viral and as a mediator of the body’s own immune-defense mechanisms. EFLA 956 is standardized on Umckalin, a constituent unique to Pelargonium sidoides. It is available as a powder extract without a carrier, offering a range of application possibilities for finished products targeting the cold-care
“This research was possible because of Biothera’s capability to isolate, modify and characterize these beta-glucan compounds,” said Dr. Underhill, associate professor, IBD and Immunobiology Research Institute, Cedars-Sinai Medical Center. For further information: www.biothera.com Bitter Orange Review Claims No Negative Side Effects A review published in Phytotherapy Research provides an indepth scientific analysis of the chemistry and safety of bitter orange drawn from 89 clinical research studies and other reference sources. The article concludes that the “preponderance of human clinical studies have reported that bitter orange extract (p-synephrine) either alone or in combination with caffeine and other ingredients has no effect on blood pressure or heart rate.” This summary of the most current research available on bitter orange contains a detailed discussion of p-synephrine receptor binding and the reasons for the absence of negative cardiovascular side effects. It also reports that 19 separate analytical studies determined that m-synephrine was not present among the protoalkaloids of bitter orange. m-Synephrine (phenylephrine), which is often found in nasal decongestants and sprays, has the potential to raise blood pressure in humans. For further information: www.nutratechinc.com Cognizin Improves Attention at ‘Low’ Dose Research conducted at the University of Utah Brain Institute revealed that individuals receiving Cognizin citicoline, from
June 2011
market, such as syrups, soft gels and tablets. For further information: www.frutarom.com
LycoRed has introduced Lyc-O-Beta 1% CWS natural beta-carotene color in powder form. The ingredient is designed to dissolve instantly when mixed with cold water and is suitable for use in a variety of applications, such as beverages, dairy, bakery and confectionery. Along with providing natural color, the Lyc-o-Beta formulation ensures the daily dietary requirement for vitamin A. Natural betacarotene is also a potent antioxidant. LycO-Beta 1% CWS is highly stable to heat, light and oxygen, as well as across a wide range of pH. This new colorant allows variations in shade from vibrant yellow to orange and delivers a natural and healthy color to existing and new formulations. For further information: www.lycopene.com
Kyowa Hakko, at a dose of 250 mg showed improved attention and a better ability to produce correct responses in performance testing. Participants who were administered either the 250 mg or the 500 mg dose of Cognizin produced nearly identical results when compared to the placebo group, confirming that 250 mg is an efficacious dose for producing improvements in attention. Findings were presented by Erin McGlade, PhD, Research Fellow at the Brain Institute, at the 66th Annual Meeting of the Society of Biological Psychiatry in San Francisco. Subjects in this double-blind, placebo-controlled three-arm study designed to evaluate the effectiveness of Cognizin citicoline on attentional function included 60 healthy women ages 40-60. Participants were divided into three groups of 20 and then completed a clinical screening visit, including a medical exam. After enrollment, each subject began supplementation with a daily oral dose of either 250 mg (low dose) or 500 mg (high dose) of Cognizin citicoline or placebo for 28 days. Participants were then evaluated with the Continuous Performance Test II (CPT-II), a measure sensitive to attentional function. Results after supplementation showed that individuals receiving either the low or high dose of Cognizin citicoline produced fewer commission errors on the CPT-II compared to the placebo group. Specifically, individuals in the two Cognizin citicoline supplemented groups made fewer errors when responding to non-target stimuli. These findings suggest improved attention when required to inhibit incorrect responses. For further information: www.cognizin.com
www.nutraceuticalsworld.com
Nutraceuticals World • 63
People in the News Tolworthy
Cantox Health Sciences Inc., an Intertek company, announced that Dr. Ian Munro passed away at the age of 71 following his battle with cancer. As one of the founding shareholders of Cantox in 1985 and an esteemed scientist, Dr. Munro led Cantox as president from 1990 to 2006. Wisdom Natural Brands, Gilbert, AZ, has appointed Laura Setzfand vice president of sales. She will be responsible for targeting specific areas of growth across diverse channels of distribution while managing a new team of sales associates dubbed the “Sweet Team.” Claire Polson, eastern region sales manager, has a background that includes more than 17 years of sales and marketing experience in natural/specialty products. Kendall Clemens, central region sales manager, brings more than 16 years of sales experience to the team, with a background working with Balance Bar Company and Atkins Nutritionals. Leann Maxwell-Muir, western region sales manager, brings 20 years of experience in sales and marketing management to the team, having worked with the Kashi Company. Twinlab Corporation, New York, NY, has appointed Tom Tolworthy president and CEO. His experience includes 10 years with The Vitamin Shoppe, including six years as CEO.
Schiff Nutrition International, Salt Lake City, UT, has appointed Jon Fieldman senior vice president—Operations. He previously served as vice president, Specialty Supply Chain for the Clorox Company. The company has also announced the retirement of Thomas Elitharp, executive vice president, Operations and Support Services. Skinny Nutritional Corp., Bala Cynwyd, PA, has promoted Tarik Ferron to vice president of DSD Sales. He will be responsible for strengthening the company’s current organization of distributors and completing the national distribution network for Skinny Water. Standard Process Inc., Palmyra, WI, has hired Michael Kemp, PhD, as research scientist, and Kristi Prokop as human resources representative. In addition, the company promoted Trisha Zarling to graphic designer. Mr. Kemp will help provide evidence-based research related to the effectiveness of specific whole food supplements. Ms. Prokop will assist Standard Process with its pension and profit plan administration, educational assistance program and recruitment initiatives. USANA Health Sciences, has announced that Fred Cooper, president and COO; Jeffrey Yates, CFO; and Mark Wilson, executive vice president of sales, have each
stepped down from their respective offices to pursue other business endeavors. The company has realigned its executive team and appointed Kevin Guest as president of North America, Deborah Woo as president of Asia Pacific, G. Douglas Hekking as CFO and Roy Truett as COO. Regan Miles has joined Next Pharmaceuticals, Salinas, CA, as president. He previously served as president and CEO of Univera, Inc., where he achieved significant annual growth and launched 10 proprietary nutritional products in three years. As a 30year veteran of the health industry, he has also worked at Nature’s Way, Alphine Health Industries and Unigen. The Council for Responsible Nutrition (CRN), Washington, D.C., has hired Taylor Wallace, PhD, as senior director, Scientific & Regulatory Affairs. He previously served as the scientific communications program manager at the International Life Sciences Institute (ILSI), North America. In his new position at CRN, Dr. Wallace will join his colleagues in interpreting and contributing to the scientific literature surrounding dietary supplements and nutrition, as well as working with CRN’s member companies on a variety of regulatory issues affecting the supplement industry.
Classifieds Executive Marketing Position Wanted Are your products underrepresented? Not living up to their sales potential? Do you wish to establish a respectful presence in the US market or significantly improve your corporate sales position? If you manufacture uniquely superior nutraceuticals rooted in sound science coupled with proven efficacy we should talk! I am a veteran, North East based, technical sales & marketing professional with my most recent experience being 18 years in the pharmaceutical and dietary supplement industries. I possess a MS in human nutrition, clinical nutrition certification, schooled in manufacturing tablets and hard/softgel capsules. Also GMP and QC/QA savvy. I have formulated best selling dietary supplements currently marketed to health care practitioners and the health food retail marketplace. Principals only please respond to [email protected] 64 • Nutraceuticals World
www.nutraceuticalsworld.com
June 2011
2011 Calendar
JUNE Jun. 28-30: HBA Global Expo & Conference, New York, NY: HBA, Contact: Ellen Evers, 609-759-4700; E-mail: [email protected]; Website: www.hbaexpo.com
Website: www.vitafoodsasia.com Sep. 22-24: Natural Products Expo East, Baltimore, MD: New Hope Natural Media, 866-458-4935; E-mail: [email protected]; Website: www.expoeast.com
JULY
OCTOBER
Jul. 19-22: The 14th Annual NBJ Summit, Dana Point, CA: New Hope Natural Media, 866-458-4935; E-mail: [email protected]; Website: www.nbjsummit.com
Oct. 8-12: Anuga, Cologne, Germany: Koelnmesse, 773-714-0063; E-mail: [email protected]; Website: www.anuga.com Oct. 10-14: SupplySide West, Las Vegas, NV: Virgo Publishing, Contact: Amy Sharman, 480-990-1101; E-mail: [email protected]; Website: www.supplysideshow.com Oct. 12-13: Elderly & Medical Foods 2011, Amsterdam, The Netherlands: Bridge2Food, Contact: Gerard Klein Essink, 31-30-225-2060; E-mail: [email protected]; Website: www.bridge2food.com/emc2011.asp Oct. 16-19: 2011 AACC International Annual Meeting, Palm Springs Convention Center, Palm Springs, CA: AACC Inter-
AUGUST Aug. 16-18: 9th International Conference on Functional Food Components in Health & Disease, San Diego, CA: Functional & Healthy Food Center, 866464-6955; E-mail: [email protected]; Website: www.functionalfoodscenter.net
SEPTEMBER Sep. 7-9: Vitafoods Asia, Hong Kong: Vitafoods, Contact: Phil Hawkins, 44-207240-2444; E-mail: [email protected];
national, Contact: Rhonda Wilkie, 651454-7250; E-mail: [email protected]; Website: http://meeting.aaccnet.org Oct. 19-22: CRN Annual Conference & Workshop, Rancho Palos Verdes, CA: Council for Responsible Nutrition (CRN), Contact: Katie Stevenson, 202-204-7682; Fax: 202-204-7701; E-mail: [email protected]; Website: www.crnusa.org
NOVEMBER Nov. 12: Nutrition Issues in Codex: Health Claims and Nutrient Reference Values, Bad Soden, Germany: CRN-International, 202-204-7682; E-mail: [email protected]; Website: www.crn-i.ch. Nov. 14-17: International Society for Nutraceuticals & Functional Foods (ISNFF) Annual Conference, Sapporo, Japan: ISNFF, 709-864-4000; E-mail: [email protected]; Website: www.isnff.org Nov. 29-Dec. 1: Food Ingredients Europe, Paris, France: United Business Media, 31-20-40-99-544; E-mail: [email protected]; Website: www.ingredientsnetwork.com
Advertisers Index Advertiser AACC International Alpha Packaging Capsugel Cognis Nutrition & Health Consumer Product Testing Company Dr. Paul Lohmann, Inc. DSM Nutritional Products Inc. Ecuadorian Rainforest Food Ingredients Europe Gnosis USA Inc. HBA iTi tropicals LycoRed Corp OmniActive Health Technologies Pharmachem Laboratories Proprietary Nutritionals Inc. SanHerb Solbar Wacker Chemical Corp. Welch, Holme & Clark June 2011
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meeting.aaccnet.org www.alphap.com www.capsugel.com www.cognis.com www.cptclabs.com www.lohmann-inc.com www.unlimitednutrition-na.dsm.com www.intotherainforest.com www.ingredientsnetwork.com/fieurope www.gnosis-bio.com www.hbaexpo.com 609-987-0252 www.iTitropicals.com 973-882-0323 www.lycored.com 877-588-3629 www.omniactives.com 201-246-8105 www.pharmachemlabs.com 519-647-3986 www.perluxan.com www.sanherb.com 651-528-6728 www.solbar.com www.wacker.com/food 973-465-7332 www.welch-home-clark.com Nutraceuticals World • 65
Nutraceuticals Multiverse A quirky account of what could/may be happening in parallel universes/dimensions.
Setting: Galen Galactic Medicine Centre, Quarkville, V12.65.aa, 29 August 2011. David Browne, Nurse Practitioner: “Good morning Mr. and Mrs. Paquet. Nice to see you again. (David casts his gaze upon the identical twin daughters of Mr. and Mrs. Paquet). Good morning, Teresa and Cristina! Well it’s been three weeks since your last visit. Have the girls had any side effects or problems with the probiotics that Dr. Ben-
Eviscerating ‘Evidence’: A Gut Feeling What if there was a way to objectively evaluate the consumer-relevant efficacy of a probiotic, in a physician’s office?
By Anthony Almada
Anthony L. Almada, B.Sc., M.Sc., is the president and CEO of GENr8, Inc., aninnovator and marketer of evidence-based performance nutrition products. He has worked in the nutrition industry since 1975 and has abundant experience in product and ingredient innovation, IP, clinical research, and science-driven marketing. Mr. Almada can be reached at 332545 B Golden Lantern, PMB 477, Dana Point, CA 92629; 949-218-9779; E-mail: [email protected]; Website: www.genr8speed.com. 66 • Nutraceuticals World
son gave them at your last visit?” Mrs. Paquet: “We have all done fine with them, except last Wednesday Teresa did have one day of loose stools, but I think that’s from her eating a little too much honey on her toast that morning. She—”[audible tone emits from the front desk.] David Browne:“Oh. There’s Dr. Benson. I’ll escort all of you back to the scan room. Come through the EnteroScan, girls, one at a time, please.”[Paquet girls walk through the EnteroScan, as requested, and enter into the scan room.] Dr. Roxann Benson: “Good morning Paquet family! Hi girls! Please have a seat. I heard the conversation you had with David about your tolerability of the different probiotics I gave you all last week. Now Teresa, your tummy sometimes has a tough time letting a certain sugar called fructose to enter inside your body, and that can cause you to have a tummy ache or even diarrhea. We doctors call it fructose intolerance. If you don’t want to have a tummy ache or diarrhea just try to use a smaller serving, ok? [Teresa nods affirmatively, slightly embarrassed.] Cristina, I’m surprised you don’t have it! “Ok! Let’s look at some really cool picwww.nutraceuticalsworld.com
tures and readings from the EnteroScan, for you two girls. [Dr. Benson reaches for a touch screen tablet with a variety of virtual buttons and symbols. The lights dim and visual images appear on one of the walls.] Let’s start with you, Cristina. Do you see the colored bars there with today’s date, and how high the green bar is [a virtual pointer, guided by Dr. Benson’s gaze, circles around a green bar among a series of other vertical bars]? Now let’s compare this green bar to what your body showed when you took the other probiotic two months ago…[another green bar appears, of a notably smaller scale]. Now I’ll show Teresa’s scan [scan data appear to right of Cristina’s]. Now with Cristina’s we see a pretty tiny green bar, but a really tall pink bar. Let’s compare to your last scan…[new bars appear]. Wow! That’s a big change, Cristina.” Mr. Paquet: “Doctor, I forget what the EnteroScan measures? Would you re-educate me, please?” Dr. Benson: “Certainly. When the girls walked through the airtight EnteroScan chamber both their breath and intestinal gases were measured. We know from a lot of research that probiotics, herbal extracts, certain spices, and even herbal teas can change the number and metabolism of the bacteria that live in the intestines. Just one cup of chamomile tea can reset or ‘switch’ the metabolism in the intestines and the body for a few weeks. The bars we’re looking at reflect different types of metabolism shifts in the intestines of the girls. The really small green, and high pink bar for Teresa shows how the unabsorbed fructose in honey affects her intestinal metabolism, but otherwise the girls showed pretty identical changes. Now you thought that I gave the girls the same probiotic but actually one of them—for Teresa—had live bacteria, while the one for Cristina was the exact same ‘bug’ but we ‘killed’ it with heat. But they both worked, and better than the last one we gave you girls, where they were both alive. NW I’m pleased.” June 2011
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